Active and passive intervention conbined with characteristic treatment regimens of traditional Chinese medicine in mild cognitive impairment: a multicentre, randomized control study

Not Applicable

Conditions: Mild cognitive impairment

Registration Number: ITMCTR2000003223

Lead Sponsor: Beijing University of Chinese Medicine

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

1. Patients meeting MCI diagnostic criteria;
According to the MCI diagnostic criteria developed by the National Institute of aging (NIA) and the Alzheimer's Association (ADA) in 2011:
(1) Memory function decreased;
(2) The continuous decline of cognitive function lasted from several months to one year;
(3) Excluding Parkinson's disease and hallucinations;
(4) Imaging showed that there were no risk factors or extensive cerebrovascular diseases;
(5) There are no obvious behavioral and language barriers.
2. For patients whose MOCA score is less than 26, if the education period is less than or equal to 12 years, 1 point will be added on the basis of the score;
3. Patients between 50 and 75 years old;
4. Those who have not regularly carried out various forms of exercise for more than three times a week for at least 20 minutes in the last six months;
5. Subjects with informed consent and voluntary participation.
Only those who meet all the above conditions can be included in the study.

Exclusion Criteria

1. Hypertension patients with uncontrollable blood pressure (diastolic blood pressure still exceeds 100mmhg or systolic blood pressure still exceeds 160mmhg);
2. Patients with a history of serious alcohol and drug abuse;
3. Patients with cognitive impairment caused by depression;
4. Patients with cognitive impairment caused by poisoning or drugs;
5. Patients with a history of mental illness (such as personality disorder, schizophrenia, etc.), severe aphasia and audio-visual disorder, or with severe organ failure, musculoskeletal system disease, coronary heart disease, myocardial infarction, musculoskeletal system disease and other contraindications of sports therapy;
6. Subjects who are participating in other clinical trials and will affect the outcome evaluation of this study.