Helmet Continuous Positive Airway Pressure Versus High Flow Nasal Cannula Oxygen in Acute Cardiogenic Pulmonary Oedema: A Randomized Control Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiogenic Pulmonary Edema
- Sponsor
- Hospital Raja Permaisuri Bainun
- Enrollment
- 188
- Locations
- 1
- Primary Endpoint
- Respiratory Rate
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This study objectively held to compare the physiological outcomes in the non-invasive (NIV) treatment of Acute Cardiogenic Pulmonary Oedema (ACPE) patients in the Emergency Department (ED) delivered by Helmet CPAP (hCPAP) and HFNC.Patients will be randomized to receive either hCPAP or HFNC.
Detailed Description
Non-invasive ventilation(NIV) has different types of interfaces that had been used in acute hypoxaemic and hypercapnic respiratory failure. The appropriate interface is necessary to provide comfort and lead to the success of NIV. Helmet continuous positive airway pressure (hCPAP) is an NIV interface that allows the provision of high airway pressures with a minimal leak. HFNC which delivers heated humidified high flow oxygen provides a good alternative to the conventional NIV in terms of comfort
Investigators
Dr. Adi Bin Osman
EMERGENCY MEDICINE CONSULTANT
Hospital Raja Permaisuri Bainun
Eligibility Criteria
Inclusion Criteria
- •All patients aged more than 18 years old presented with acute cardiogenic pulmonary oedema.
Exclusion Criteria
- •Age less than 18 years old
- •Low GCS (less than 8), altered mental status
- •Hemodynamic instability, impending cardiopulmonary arrest
- •Use of vasopressors, inotropes
- •Exacerbation of asthma or chronic respiratory failure
- •Urgent need for endotracheal intubation
- •Absence of airway protective gag reflex
- •Elevated intracranial pressure
- •Tracheostomy
- •Upper airway obstruction
Outcomes
Primary Outcomes
Respiratory Rate
Time Frame: 1 hour
Respiratory rate reduction post intervention
Secondary Outcomes
- Heart Rate(1 hour)
- Heart Rate,Acidosis (pH), Consciousness (GCS), Oxygenation (PF ratio) And Respiratory Rate(HACOR) Score(1 hour)
- Ratio Of Partial Pressure Arterial Oxygen And Fraction Of Oxygen(1 hour)
- Dyspnoea Scale(1 hour)
- Partial Pressure Of Arterial Oxygen Level(1 hour)
- Rate Of Intubation(1 hour)
- 28-Days Mortality In Acute Cardiogenic Pulmonary Edema(28 days)