Continuous Non-invasive Hemodynamic Monitoring in Early-onset Severe Preeclampsia: a Comparison of Echocardiography, Bioreactance, and Finger Cuff Measurements
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Change in cardiac output (L/min) as measured by NICOM (bioreactance) monitoring
研究概览
简要总结
The purpose of this study is to compare the feasibility and accuracy of two methods of non-invasive hemodynamic assessments - bioreactance as assessed by non-invasive cardiac output monitoring (NICOM; Cheetah Medical) and pulse wave analysis as assessed by finger cuff arterial pressure (ClearSite, Edwards Life Sciences) - compared to hemodynamic assessments by intermittent echocardiography in early onset preeclampsia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •BP >160 or DBP >110
- •gestational age between 20-34 weeks
- •singleton pregnancy
排除标准
- •prior diagnosis of chronic hypertension or hypertensive disorder of pregnancy
- •multi-fetal pregnancy
结局指标
主要结局
Change in cardiac output (L/min) as measured by NICOM (bioreactance) monitoring
时间窗: Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum)
Cardiac output (L/min) ranges 3-10 L/min, lower values associated with more severe preeclampsia
Change in systemic vascular resistance (dynes/sec*cm-5) as measured by NICOM (bioreactance) monitoring
时间窗: Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum)
Systemic vascular resistance ranges 600-2000 dynes/sec\*cm-5, higher values associated with more severe preeclampsia
Change in Cardiac output (L/min) as measured by Clearsite (pulse wave analysis) monitoring
时间窗: Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum)
Cardiac output (L/min) ranges 3-10 L/min, lower values associated with more severe preeclampsia
Change in Cardiac output (L/min) as measured by transthoracic echocardiography
时间窗: Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum)
Cardiac output (L/min) ranges 3-10 L/min, lower values associated with more severe preeclampsia
Change in Systemic vascular resistance (dynes/sec*cm-5) as measured by Clearsite (pulse wave analysis) monitoring
时间窗: Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum)
Systemic vascular resistance ranges 600-2000 dynes/sec\*cm-5, higher values associated with more severe preeclampsiaanalysis) monitoring
Change in Systemic vascular resistance (dynes/sec*cm-5) as measured by transthoracic echocardiography
时间窗: Baseline (typically 3-5 days before birth, but can be up to 5 weeks before birth), 3 days after birth (postpartum)
Systemic vascular resistance ranges 600-2000 dynes/sec\*cm-5, higher values associated with more severe preeclampsia
次要结局
未报告次要终点