Xenon and Therapeutical Hypothermia After Successful Cardiopulmonary Resuscitation
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Significant difference between treatment group and control group
研究概览
简要总结
In this clinical trial will be checked, whether 2 hour ventilation with xenon has neuroprotective effects in patients with out of hospital cardiac arrest and successful cardiopulmonary resuscitation
详细描述
Patients with out of hospital cardiac arrest and successful cardiopulmonary resuscitation will be randomized in two groups. First group (Treatment group) will be inhalated with xenon within 2 hours in addition to therapeutical hypothermia. The second group (Control group) will be treated with therapeutical hypothermia in accordance to international guidelines.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with out of hospital cardiac arrest and successful cardiopulmonary resuscitation, which will be treated at Department of Internal Medicine I, University Hospital Aachen
排除标准
- •Patients younger than 18 years
- •Xenon allergy
- •Pregnancy
- •High expired oxygen requirement (>70%) in order to maintain adequate arterial oxygen saturation (SpO2>94%) at the beginning of treatment
研究组 & 干预措施
Xenon-Arm
Patients in Xenon-Arm will be inhalated with xenon within 2 hours additionally to therapeutical hypothermia after successful cardiopulmonary resuscitation.
干预措施: therapeutical hypothermia (Procedure)
Xenon-Arm
Patients in Xenon-Arm will be inhalated with xenon within 2 hours additionally to therapeutical hypothermia after successful cardiopulmonary resuscitation.
干预措施: Xenon Inhalation (Drug)
MTH
Patients after successful cardiopulmonary resuscitation will be treated only with therapeutical hypothermia
干预措施: therapeutical hypothermia (Procedure)
结局指标
主要结局
Significant difference between treatment group and control group
时间窗: within 28 days after cardiac arrest
次要结局
- Safety and efficacy of xenon ventilation within 2 hours after successful cardiopulmonary resuscitation(within 28 days after cardiac arrest)