Protection Against Allergy: Study in Rural Environment - Part IV

Not Applicable

Completed

• Conditions: Asthma; Atopy
• Interventions: Other: blood sampling, skin prick tests, assesment of atopic dermatitis, questionnaires

• Registration Number: NCT02929277
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

PASTURE is a birth cohort of children born to farm and non-farm women from rural areas across Europe. Five study centres Austria, Germany, Switzerland, France and Finland enrolled 1133 children (farmers in about half of the children) to study the origins of asthma and atopy and to develop potential preventive strategies.

Previous results show a protective effect of farm exposure on allergic risk by livestock contacts and microbial exposures and by raw cow milk consumption in early age.

PASTURE Part IV is the 10-year follow up of this birth cohort. The primary objective is to characterize the allergic phenotype between 6 and 10 years old (asthma and allergic rhinitis) and to explain how early age exposures and particularly milk products consumption contribute in the process of allergic illness in childhood. A focus on the characterization of the protective biologically active components in raw milk and identification of immunological mechanisms are involved.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Primary Completion: 2015-05
• Study Completion: 2015-05-06
• Study First Submitted: 2016-09-30
• Status Verified: 2016-10
• Study First Submitted QC: 2016-10-07
• Study First Posted: 2016-10-11
• Last Update Submitted: 2018-07-26
• Last Update Posted: 2018-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 131

Inclusion Criteria

• PATURE IV is a birth cohort. All children enrolled at the beginning and who still agree to participate will be included at 10-year follow-up.

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
single arm study	blood sampling, skin prick tests, assesment of atopic dermatitis, questionnaires	-

Primary Outcome Measures

Name	Time	Method
Rhinitis	10 years old
Atopic Dermatitis	10 years old
Skin prick tests	10 years old
Blood cytokine profiles	10 years old
Specific Immunoglobulin E (IgEs)	10 years old
Asthma	10 years old
Food Allergy	10 years old