Hyaluronic Acid Delivery: CO2 Laser Versus Thulium Laser Treatment

Not Applicable

Recruiting

• Conditions: Aging Skin
• Interventions: Other: CO2 laser + HA; Other: Thulium laser + HA

• Registration Number: NCT06431282
• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Brief Summary

* Weakly crossed-linked hyaluronic acid (HA) can be delivered through multiple injections into the dermal and subnormal layer to improve skin quality. However, this treatment comes with multiple bumps for several days.

* Alternatively, HA can be delivered after CO2 laser or thulium laser pretreatment. As microscopic analysis after this treatment is limited, the object of the present study is to investigate the morphological cellular changes after CO2 laser and thulium laser delivered HA into human skin.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-02-19
• Study Start: 2024-02-20
• Status Verified: 2024-05
• Study First Submitted QC: 2024-05-26
• Last Update Submitted: 2024-05-26
• Study First Posted: 2024-05-28
• Last Update Posted: 2024-05-28
• Primary Completion: 2024-05-31
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• healthy male and female patients

Exclusion Criteria

• pregnancy, breast feeding
• open wounds at the area to be treated

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CO2 laser + HA	CO2 laser + HA	Probands are treated with a CO2 laser. Afterwards a HA gel will be applied.
Thulium laser + HA	Thulium laser + HA	Probands are treated with a thulium laser. Afterwards a HA gel will be applied.

Primary Outcome Measures

Name	Time	Method
Size of keratinocytes	30 minutes and 30 days after treatment.	Size of keratinocytes after CO2 or thulium laser treatment compared to control.
Size of hyaluronic acid granules	30 minutes and 30 days after treatment.	Size of HA granules after CO2 or thulium laser treatment compared to control.
Size of intercellular spaces	30 minutes and 30 days after treatment.	Size of intercellular spaces after CO2 or thulium laser treatment compared to control.
Distribution of Hyaluronic Acid	30 minutes and 30 days after treatment.	Distribution though the epidermal and dermal layers after CO2 or thulium laser treatment compared to control.

Trial Locations

Locations (1)

University Medical-Center Hamburg-Eppendorf; 🇩🇪 Hamburg, Germany