Pharmacogenetic of the Salbutamol Efficacy in Asthma Crisis for Children in Emergency Department
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- pre- and post-bronchodilator FEV1 value (BDR = 100 x [post-FEV1 - pre-FEV1]/pre-FEV1)
研究概览
简要总结
this study is designed to identify the genetic factors which can be implicated in the salbutamol responsiveness for asthmatic children in pediatric emergency department
详细描述
Patients from 6 to 16 years old consulting for an acute asthma exacerbation and receiving a treatment by salbutamol according to the usual care could be recruited.Saliva from patient were collected using Oragen®.DNA OG-500 kit or swabs.Based on literature review, four SNP were chosen:ADBR2 gene), ARG gene, and GSNOR gene.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •6-16 years old
- •asthmatic patients
- •consulting for an exacerbation in a pediatric emergency department
- •parental informed consent
排除标准
- •comorbidity
- •peak flow no available
- •pneumonia
结局指标
主要结局
pre- and post-bronchodilator FEV1 value (BDR = 100 x [post-FEV1 - pre-FEV1]/pre-FEV1)
时间窗: Day 0
comparison of acute response to salbutamol calculated as the percentage difference between the pre- and post-bronchodilator FEV1 value (BDR = 100 x \[post-FEV1 - pre-FEV1\]/pre-FEV1) between the different polymorphism
次要结局
- polymorphism on the response delay(Day 0)
研究者
Helene Chappuy
MD Ph D
Hôpital Necker-Enfants Malades