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Clinical Trials/NCT06276712
NCT06276712
Not yet recruiting
Not Applicable

A Randomized Controlled Trial Comparing Titanium Grade V (KS) Versus Titanium Grade IV (TS) Implants for the Treatment of Edentulous Mandible

Università degli Studi di Sassari0 sites48 target enrollmentMarch 1, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Dental Implant
Sponsor
Università degli Studi di Sassari
Enrollment
48
Primary Endpoint
Rate of implant stability
Status
Not yet recruiting
Last Updated
2 years ago

Overview

Brief Summary

To evaluate the clinical and radiographic outcomes of KS implants used to rehabilitate edentulous mandible with dental-retained overdentures, and to compare it with same treatment on TS implants

Registry
clinicaltrials.gov
Start Date
March 1, 2024
End Date
January 30, 2028
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Università degli Studi di Sassari
Responsible Party
Principal Investigator
Principal Investigator

Marco Tallarico

Assistent Professor

Università degli Studi di Sassari

Eligibility Criteria

Inclusion Criteria

  • Any edentulous patient (post-extractive sites must to be healed from at least 3 months), with sufficient bone height and width in the anterior mandible (between canines) to allow the placement of two implants of 3.5 mm diameter of at least 8.5 mm of length.
  • 18 years or older, and able to sign an informed consent.
  • Smokers will be included and categorized into: 1) non smokers; 2) moderate smokers (smoking up to 10 cigarettes/day); 3) heavy smokers (smoking more than 11 cigarettes/day).
  • In case of post-extractive sites, they must have been healing for at least 3 months before being treated in the study.

Exclusion Criteria

  • Exclusion criteria
  • General contraindications to implant surgery.
  • Patients irradiated in the head and neck area.
  • Immunosuppressed or immunocompromised patients.
  • Patients treated or under treatment with intravenous amino-bisphosphonates.
  • Patients with untreated periodontitis.
  • Patients with poor oral hygiene and motivation.
  • Previous guided bone reconstruction at the intended implant sites.
  • Uncontrolled diabetes.
  • Pregnancy or nursing.

Outcomes

Primary Outcomes

Rate of implant stability

Time Frame: Up to 5 years

The stability of each individual implant will be measured by the local blinded outcome assessors manually tightening the screws with a torque of 30 Ncm at abutment connection at initial loading. At 1,3 and 5 years after loading, individual implants will be manually tested for stability. Once the single crowns will be screwed, their stability will be assessed by rocking the crown with the handles of two dental instruments.

Number of implant failure

Time Frame: Up to 5 years

Defined as implant mobility and/or any infection dictating implant removal, and/or implant fracture and/or any other mechanical complication rendering the implant unusable.

Number of prosthesis failure

Time Frame: Up to 5 years

Whether it will not be possible to place the prosthesis because of implant failure or a prosthesis that has to be remade for any reaso

Number of complications

Time Frame: Up to 5 years

echnical (fracture of the framework and/or the veneering material, screw loosening, etc.) and/or biologic (pain, swelling, suppuration, peri-implantitis, etc.) complications will be considered.

Secondary Outcomes

  • Peri-implant marginal bone level changes(At 1,3 and 5 years)
  • Patient satisfaction(At 1,3 and 5 years)

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