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Clinical Trials/NCT03747393
NCT03747393
Active, not recruiting
Not Applicable

Exploring the Value of the Veterans Affairs (VA) and Department of Defense (DoD) Clinical Practice Guidelines for Non-Surgical Management of Knee Osteoarthritis in the Military Health System

Brooke Army Medical Center3 sites in 1 country300 target enrollmentJune 1, 2019

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Knee Osteoarthritis
Sponsor
Brooke Army Medical Center
Enrollment
300
Locations
3
Primary Endpoint
Patient Reported Outcomes Measurement Information Systems (PROMIS) - Physical Function
Status
Active, not recruiting
Last Updated
3 months ago

Overview

Brief Summary

This study will compare two different treatment approaches for the management of knee osteoarthritis (OA). All subjects will receive a standardized approach consistent with the core set of recommendation from the Department of Defense (DoD) and Veterans Administration (VA) Clinical Practice Guidelines for Non-Surgical Management of Knee Osteoarthritis. Follow-up will occur over a 1 year period.

Detailed Description

There are gaps between actual clinical practice and published guidelines for management of knee OA. The VA/DoD Clinical Practice Guidelines leaves open the question of the effectiveness and cost-effectiveness of early referral to PT alongside the core set of management strategies for patients with knee OA. Prior studies have failed to include robust cost-effectiveness analyses to understand the policy implications of a recommendation to routinely refer patients with knee OA to PT in addition to implementing the core set of recommended management strategies. A comparative effectiveness parallel-group randomized controlled clinical trial examining these questions will be extremely informative for future updates of the VA/DoD Practice Guideline. The core components of the clinical practice guidelines include education on nutrition and the role of obesity in OA, as well as the role of physical activity and exercise. The physical therapy component will be based on best current evidence, and consist of manual therapy, education for self-management, and exercise.

Registry
clinicaltrials.gov
Start Date
June 1, 2019
End Date
July 1, 2027
Last Updated
3 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Dan Rhon

Director, Primary Care Musculoskeletal Research Center

Brooke Army Medical Center

Eligibility Criteria

Inclusion Criteria

  • TRICARE eligible beneficiaries (active duty, dependents, and military retired) with a primary complaint of knee pain.
  • Able to speak and read English well enough to provide informed consent, follow study instructions and independently answer the questionnaires/surveys.
  • Able to attend treatment sessions for a 4-week period.
  • Age 18-60 years old
  • The subject had an initial care visit in the last 90 days with a chief complaint of knee pain, or is scheduled to have one within the week.
  • Satisfies American College of Rheumatology (ACR) clinical criteria for diagnosis of knee OA for at least one knee.

Exclusion Criteria

  • In the last year, the subject has received any invasive interventions including injections (corticosteroid, hyaluronic acid, etc.) or surgery for their knee
  • History of Total Knee Arthroplasty (TKA)
  • Has previously received formal PT for the same knee (\> 2 visits) in the last year
  • Has consulted a surgeon for knee pain for either knee in the past year
  • History of severe neurologic (e.g., stroke, Parkinson's disease, etc.) or other condition that prevents walking independently for at least 5 minutes or engaging in a physical activity/exercise program.
  • Anyone leaving military service for other than regular retirement, pending a medical evaluation board, discharge from the military for medical reasons, or pending or undergoing any litigation for an injury.
  • Systemic disease that could otherwise be responsible for the subjects knee pain (e.g. rheumatoid arthritis, gout, or psoriatic arthritis), non-musculoskeletal conditions causing knee pain, personal history of neoplasm, current or recent knee joint infection, recent fall/trauma to knee, acute fracture of knee, lower extremity amputation, or other more likely primary musculoskeletal knee disorders (e.g. patellar tendinopathy, bursitis, runner's knee, etc.)
  • Currently has a referral to orthopedics or physical therapy for a knee disorder

Outcomes

Primary Outcomes

Patient Reported Outcomes Measurement Information Systems (PROMIS) - Physical Function

Time Frame: 2 years

The PROMIS is managed and endorsed by the NIH, and will be based on the Computer Adaptive Test, which does not have a set number of questions but instead "adapts" the test and number of questions based on prior answers it receives.

Secondary Outcomes

  • Patient Acceptable Symptom Scale (PASS)(2 years)
  • EuroQoL (EQ-5D)(2 years)
  • Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC)(2 years)

Study Sites (3)

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