Intestinal cancer and the risk for other cancer in the same perso
Not Applicable
Completed
- Conditions
- CancerAssociation between sporadic dMMR status and the risk of non-colorectal malignancy in patients with known colorectal cancer
- Registration Number
- ISRCTN11642464
- Lead Sponsor
- Cancer Research Foundation in Northern Sweden (Cancerforskningsfonden i Norrland)
- Brief Summary
2021 Thesis results in https://umu.diva-portal.org/smash/record.jsf?language=en&pid=diva2%3A1554838&dswid=7852 Doctoral thesis; study V (added 15/06/2023)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 1706
Inclusion Criteria
1. Histologically confirmed CRC
2. Stage confirmed and transformed to the American Joint Committee on Cancer (AJCC) TNM classification
3. Available clinical and pathological data regarding the course of the disease and demographic data
Exclusion Criteria
1. Patients younger than 18 years
2. Inconclusive immunohistochemical analysis (IHC) or missing data
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The risk for non-colorectal malignancy before and after this diagnosis, compared to patients with different MMR tumors is measured using Incidence Rate Ratio (IRR) in both the univariable and multivariable analyses at one timepoint
- Secondary Outcome Measures
Name Time Method Standardized incidence ratios (SIR) are calculated for each of the cancer forms reported (patients with pMMR and dMMR separately) and adjusted for sex, year (in one-year classes), and age (in five-year classes) at one timepoint