NCT01397136已完成不适用
Cell-free DNA: a Non-invasive Test for Assessing Embryo Quality
IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy1 个研究点 分布在 1 个国家目标入组 600 人开始时间: 2011年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Isolation and characterization of nuclear and/or mitocondrial DNA into embryo culture medium
研究概览
简要总结
In the present project we propose to deeply characterize nuclear and/or mitochondrial DNA in embryo culture medium, in order to investigate whether both cell-free nucleic acid types may provide additional, reliable, predictive parameters for embryo viability and implantation potential.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Days 至 7 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •We will enroll in the study only embryos obtained from fresh gametes. It is to note that we currently transfer more than one embryo (with a maximum of 3, according to patient's age) and we will follow such criteria alongside the project. Consequently, we will take into consideration this aspect in correlating DNA parameters with embryo's outcome.
排除标准
- •We will exclude cryopreserved embryos, in order to avoid potential biases due to cooling/defrosting procedures.
结局指标
主要结局
Isolation and characterization of nuclear and/or mitocondrial DNA into embryo culture medium
时间窗: Month 6 of the project
次要结局
- Prediction of high quality embryos according to molecular profiling of cell-free DNA released into culture medium.(Month 12 of the project)
- Publication of scientific reports.(Month 12 of the project)
- Dissemination of results by participating at national and international meetings, workshops and specific courses.(Months 3-12 of the project)
研究者
Paola Scaruffi
Dr
IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
研究点 (1)
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