Serum and Urine Metabolome Studies in Patients With Acute Kidney Injury After Cardiac Surgery

Active, not recruiting

• Conditions: Cardiac Surgery Associated Acute Kidney Injury

• Registration Number: NCT06245720
• Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Brief Summary

The goal of this observational study is to learn about serum and urine metabolome in patients after cardiac surgery.

Detailed Description

The main objective of this study is to collect blood and urine samples from patients after cardiac surgery, and to perform metabolomic analysis to find the differential metabolites and their enrichment pathways in AKI patients and non-AKI patients.The secondary objective is to intervene in its enrichment pathway to find ways to improve CSA-AKI.

Study Timeline

• Status Verified: 2024-01
• Study Start: 2024-01-01
• Study First Submitted: 2024-01-30
• Study First Submitted QC: 2024-01-30
• Last Update Submitted: 2024-01-30
• Study First Posted: 2024-02-07
• Last Update Posted: 2024-02-07
• Primary Completion: 2024-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Age> 18 years old;
2. after cardiopulmonary bypass;

Exclusion Criteria

1. Under the age of 18;
2. Previous chronic kidney disease or receiving renal replacement therapy;
3. Have a history of kidney transplantation or nephrectomy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum and urine metabolome studies	January 2025 - December 2025	The preoperative and postoperative metabolomic differences in blood and urine between AKI group and non-AKI group were compared.

Trial Locations

Locations (1)

Nanjing First Hospital; 🇨🇳 Nanjing, China