Brain and Cognitive Reserve

Not Applicable

Completed

• Conditions: Brain Ischemia
• Interventions: Other: neurologic and neuropsychological evaluation

• Registration Number: NCT02819167
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Ischemic strokes are one of the leading causes of handicap and death in elderly people in France.

Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental factors that explain differential susceptibility to functional impairment in the presence of pathology or other neurological insult. CR is estimated using variables for cognitive activity: years of education, professional status, socioeconomic status... Furthermore, brain reverse (BR) is a passive and quantitative model that depend on brain size and other quantitative aspects of the brain that explain differential susceptibility to functional impairment in the presence of pathology.

Firstly, volume and localization of ischemic strokes have a great impact on CR and BR due to brain injury. On the other hand, CR influences the severity and the expression of cognitive diseases.

The investigators realize a prospective study in order to assess the impact of CR and BR on cognitive prognosis after a right middle cerebral artery ischemic stroke in elderly patients.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2016-05-26
• Study First Submitted: 2016-06-28
• Study First Submitted QC: 2016-06-29
• Study First Posted: 2016-06-30
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-16
• Last Update Posted: 2017-11-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• ≥70 years old
• right middle cerebral artery ischemic stroke
• hospitalized in neurovascular unit of Pierre Wertheimer hospital between January 2015 to January 2016

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Exclusion Criteria

• Contraindication for MRI
• Hemorrhagic stroke
• Aphasia

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
neurologic and neuropsychological evaluation	neurologic and neuropsychological evaluation	-

Primary Outcome Measures

Name	Time	Method
evaluation of cognitive prognosis	one year post Ischemic stroke	measure will be performed with the Mattis dementia rating scale

Secondary Outcome Measures

Name	Time	Method
Volume of leucoencephalopathy	one year post Ischemic stroke	measure will be performed with a MRI
volume of hippocampic	one year post Ischemic stroke	measure will be performed with a MRI
brain injury	one year post Ischemic stroke	measure will be performed with a MRI
volume of ischemic stroke	one year post Ischemic stroke	measure will be performed with a MRI
evaluation of cognitive reserve	one year post Ischemic stroke	measure will be performed with the Cognitive reserve index questionnaire

Trial Locations

Locations (1)

Hôpital des Charpennes; 🇫🇷 Lyon, France