Profiling Parkinson’s disease
- Conditions
- Parkinson's disease
- Registration Number
- NL-OMON21445
- Lead Sponsor
- Amsterdam UMC, location VUmc
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1515
Patients
In order to be eligible to participate in this study, a patient must meet ALL of the following criteria:
- Recently diagnosed with PD (N=625; time since Parkinson diagnosis = 2 years) or not recently diagnosed with PD (N=625; time since Parkinson diagnosis > 2 & = 10 years) (Time since Parkinson diagnosis (in years) made by a neurologist according to the Movement Disorder Society clinical diagnostic criteria for Parkinson's disease; In order to obtain a good representation of the PD population an even distribution with respect to gender and age (age categories: <55 years, 55-65 years and >65 years) in both patient groups, will be attempted;
- 18 years or older;
- Able to read and understand Dutch;
- Providing IRB-approved Informed Consent;
- Willing, competent and able to comply with all aspects of the protocol, including follow-up schedule and biospecimen collections.
Controls
- 18 years or older;
- Healthy (self-report);
- Similar distribution with respect to gender and age as the patient groups will be attempted;
- Providing IRB-approved Informed Consent;
- Willing, competent and able to comply with all aspects of the protocol, including follow-up schedule and biospecimen collections.
A potential participant who meets ANY of the following criteria will be excluded from participation in this study:
Patients
- Patients who received brain surgery for Parkinson’s disease, patients who currently use levodopa continuous intestinal gel or patients who are currently receiving apomorphine treatment.
- Presence of co-morbidities that would hamper interpretation of parkinsonian disability, in the opinion of the investigator;
- MoCa score of =16 (indicates dementia);
- Unwillingness to be informed of unexpected medical findings;
- Note: patients with a disease duration of = 2 yrs, are excluded if:
- they are current, recent or past participant in The Personalized Parkinson Project (de Parkinson op maat studie”) from Radboudumc.
- Patients with a disease duration of > 2 & = 10 yrs, are only excluded if they are currently a participant in The Personalized Parkinson Project (de Parkinson op maat studie”) from Radboudumc.
Controls
- A history of neurological disorders that affect the brain or central nervous system;
- Abnormal findings at general neurological examination;
- Unwillingness to be informed of unexpected medical findings.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method