Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
研究概览
简要总结
This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.
详细描述
Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol
排除标准
- •History of any skin disease
结局指标
主要结局
Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
时间窗: 1 day
Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
次要结局
- Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy(1 day)