Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Rockefeller University
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.
Detailed Description
Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol
Exclusion Criteria
- •History of any skin disease
Outcomes
Primary Outcomes
Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
Time Frame: 1 day
Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy
Secondary Outcomes
- Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy(1 day)