effects of taurine in traumatic brain injury
Phase 2
Recruiting
- Conditions
- traumatic brain injury.Diffuse traumatic brain injury
- Registration Number
- IRCT20180514039657N1
- Lead Sponsor
- Ahvaz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
At least 18 years old
GCS=6-12
traumatic brain injury patients
receive entral nutrition
Exclusion Criteria
Taking anti-inflammatory drugs or corticosteroids before entering the study
Patients with liver or kidney disorders
Pregnant or lactating women
Patients with Congenital Amino Acid Metabolism Disorder
Failure to provide more than 60% of the energy and protein requirement calculated through entral nutrition in the first week
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method High sensitive C-Reactive Protein. Timepoint: The beginning and end of the study. Method of measurement: ELISA.;Tumor Necrosis Factor-alpha. Timepoint: The beginning and end of the study. Method of measurement: ELISA.;Interleukin-6. Timepoint: The beginning and end of the study. Method of measurement: ELISA.;Interleukin-10. Timepoint: The beginning and end of the study. Method of measurement: ELISA.;Weight. Timepoint: The beginning and end of the study. Method of measurement: Patient bedside scale.;Clinical outcome measurement. Timepoint: day 1,7,14. Method of measurement: Sequential Organ Failure Assessment(SOFA) score.;Disease severity. Timepoint: day 1,14. Method of measurement: APACHEII score.
- Secondary Outcome Measures
Name Time Method 30-day mortality. Timepoint: day 30. Method of measurement: Contact with patient's family.;Length of stay to ICU. Timepoint: daily. Method of measurement: observation.;Malnutrition. Timepoint: The beginning and end of the study. Method of measurement: subjective global assessment.;Dependence on ventilator. Timepoint: daily. Method of measurement: Counting the number of ventilator attachment days.