NCT00683059已完成2 期
A Multi-Institutional Phase II Study of Single Agent Abraxane as Second Line Therapy in Patients With Advanced Transitional Cell Carcinoma of the Urothelium
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 5
- 主要终点
- Response rate
研究概览
简要总结
The purpose of this study is to determine what effects the drug Abraxane has on bladder cancer.
详细描述
For those patients with advanced bladder cancer who have progressed on a platinum based regimen, no widely accepted standard second line therapy currently exists. Taxanes including paclitaxel have exhibited clinical activity in this disease and are sometimes given off study. However, toxicities including neurotoxicity and hypersensitivity reactions often limit the use of paclitaxel. ABRAXANE may allow delivery of a greater dose of paclitaxel to those with bladder cancer with an easier method of administration and with less toxicity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have histological or cytological diagnosis of urothelial carcinoma. Mixed histologies are permitted as long as transitional cell carcinoma is the major component (i.e. >50% of the pathologic specimen). Pure or predominant squamous cell carcinomas are not permitted.
- •Patients with transitional cell carcinomas of the renal pelvis and ureter are permitted.
- •Patients must have metastatic or locally advanced unresectable disease.
- •Patients must have received one and only one prior chemotherapeutic regimen which included a platinum (at least one cycle) for metastatic/recurrent disease. Neoadjuvant or adjuvant chemotherapy will be considered to have been first line if the patient progressed within 12 months of the last dose.
- •Neoadjuvant/adjuvant chemotherapy (with or without a taxane) is permitted if registration is greater than 12 months since the last dose (patients must then have received one platinum containing regimen in the metastatic setting)
- •ECOG performance status <=
- •Estimated life expectancy of >12 weeks.
- •Patients must have measurable disease according to RECIST criteria.
- •If female of childbearing potential, pregnancy test is negative within 72 hours priors to first dose of study drug.
- •If fertile, patient agrees to use an effective method of contraception to avoid pregnancy for the duration of the study.
- •Adequate organ function; Absolute neutrophil count >1.5 x 109/L. Platelet count >100 x109/L. Hemoglobin >90 g/L. Total bilirubin <1.5x upper limit of normal. Transaminases <3x upper limit of normal (<5x if liver metastasis are present) Calculated creatinine clearance >40 ml/min (Cockcroft & Gault formula)
- •Able to give informed consent.
排除标准
- •Prior taxane therapy for metastatic disease (or > 12 months since a taxane-containing neoadjuvant or adjuvant chemotherapy).
- •Pre-existing peripheral neuropathy >1 by NCI-CTC criteria.
- •Pregnant or lactating females.
- •Uncontrolled brain or leptomeningeal involvement (treated brain metastasis permitted if both known lesions and medications e.g. steroids for that indication are stable).
- •History of serious or concurrent illness that might be aggravated by study treatment.
- •History of class II-IV congestive heart failure.
- •Other malignancies except adequately controlled basal cell carcinoma of the skin or carcinoma in situ of the cervix or incidental prostate cancer (T1a, Gleason <7 PSA <10ng/ml) or any other tumor within 5 years prior to enrollment.
- •Other investigational therapy or radiation therapy within 30 days before registration.
- •Patients not willing to employ adequate contraception for the duration of the study.
研究组 & 干预措施
Nab-paclitaxel
Experimental
干预措施: Paclitaxel (Drug)
结局指标
主要结局
Response rate
时间窗: one year
次要结局
- safety(1 year)
- overall survival(1-2 years)
研究者
研究点 (5)
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