Alleviation of Hypercholesterolemia Through Newly Developed Cookies Supplementedwithpumpkin (Cucurbita Pepo L.) Seeds and Walnuts (Juglans Regia L.) Among Arthrosclerosispatients.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Change in LDL Cholesterol
研究概览
简要总结
This study is being conducted at DHQ Hospital, Jhang, under the supervision of the University of Lahore. The purpose of the trial is to find out whether specially prepared cookies made with pumpkin seeds (Cucurbita pepo L.) and walnuts (Juglans regia L.) can help improve cholesterol levels in patients with atherosclerosis.
High cholesterol is one of the major causes of heart disease and stroke. Although medicines are commonly prescribed, adding natural foods with proven health benefits may help patients manage cholesterol in a safer and more affordable way. Pumpkin seeds contain healthy fats, antioxidants, and phytosterols, while walnuts provide omega-3 fatty acids, fiber, and vitamins. Together, they may improve heart health by lowering harmful cholesterol (LDL) and increasing good cholesterol (HDL).
In this study, patients will be divided into two groups:
Treatment group: Will receive one 100 g cookie made with pumpkin seeds and walnuts every day, in addition to their usual care.
Control group: Will receive usual care without the supplemented cookies.
Blood samples will be taken at the start, at 3 weeks, and at 6 weeks to measure cholesterol, triglycerides, LDL, and HDL levels. Researchers will follow up with participants regularly to ensure safety and compliance.
The study will help determine whether these cookies can be recommended as a natural, food-based approach to reducing cholesterol and preventing complications of heart disease.
详细描述
Background
Hypercholesterolemia and dyslipidemia are significant modifiable risk factors for atherosclerosis and cardiovascular disease (CVD). Current pharmacological therapies, though effective, are often limited by side effects, cost, and accessibility. Functional foods containing bioactive compounds are gaining attention as adjunct strategies for lipid management.
Pumpkin (Cucurbita pepo L.) seeds are rich in phytosterols, unsaturated fatty acids, magnesium, and antioxidants, all of which may positively influence lipid metabolism. Walnuts (Juglans regia L.) provide polyunsaturated fatty acids (PUFAs), fiber, polyphenols, and essential minerals that have been shown to lower LDL cholesterol and improve endothelial function. Combining these ingredients in an acceptable dietary form may provide synergistic cardioprotective benefits.
Objectives
Primary Objective:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
盲法说明
this is an open level trial
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of both gender Patients with age 25-45 years will be included Having HDL value greater than ~60 mg/dL Having triglycerides value greater than150 mg/dL
排除标准
- •Pregnant and lactating patients will be excluded. Cancer patient will be excluded
结局指标
主要结局
Change in LDL Cholesterol
时间窗: Baseline, 3 weeks, and 6 weeks
Absolute change in serum LDL cholesterol (mg/dL) from baseline to week 6. Blood collected after overnight fast; analyzed by enzymatic methods in hospital lab.
次要结局
- hange in HDL Cholesterol(Baseline, 3 weeks, and 6 weeks)
研究者
Kamran Hanif
assistant professor
University of Lahore