Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

Phase 1

Completed

• Conditions: Carpal Tunnel Syndrome
• Interventions: Procedure: neural mobilization; Other: healthy controls; Procedure: sham neural mobilization

• Registration Number: NCT00929123
• Lead Sponsor: University of Florida

Brief Summary

The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in individuals with carpal tunnel syndrome. The investigators hypothesized that individuals receiving a neural mobilization technique known to directly stress the median nerve would demonstrate greater improvements in clinical pain and function, experimental pain sensitivity, and median nerve function than those receiving a sham technique.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05
• Primary Completion: 2008-07
• Study Completion: 2009-06
• Study First Submitted: 2009-06-25
• Study First Submitted QC: 2009-06-25
• Study First Posted: 2009-06-26
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-12
• Last Update Posted: 2015-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 18 to 70 years of age
• signs and symptoms of carpal tunnel syndrome for greater than 12 weeks

Exclusion Criteria

• non english speaking
• prior surgery for carpal tunnel syndrome
• systemic condition known to affect sensation
• chronic pain condition other than carpal tunnel syndrome

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
neural mobilization	neural mobilization	manual therapy technique known to directly stress the median nerve
Healthy Controls	healthy controls	People without carpal tunnel syndrome for comparison
sham neural mobilization	sham neural mobilization	manual therapy technique known to directly stress the median nerve without any stimulation.

Primary Outcome Measures

Name	Time	Method
thermal and pressure pain sensitivity	immediate effect

Secondary Outcome Measures

Name	Time	Method
clinical pain	3 weeks
median nerve function	3 weeks
wrist range of motion	3 weeks
self report of disability	3 weeks
grip strength	3 weeks

Trial Locations

Locations (1)

University of Florida; 🇺🇸 Gainesville, Florida, United States