ISRCTN81956288
Completed
未知
The effect of n-3 polyunsaturated fatty acid (PUFA) supplementation in patients with steatosis due to non-alcoholic fatty liver disease
niversity of Nottingham (UK)0 sites58 target enrollmentMay 19, 2010
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Topic: Metabolic and Endocrine
- Sponsor
- niversity of Nottingham (UK)
- Enrollment
- 58
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Age greater than 18 years, either sex
- •2\. Liver biopsy showing NAFLD
Exclusion Criteria
- •1\. Excessive alcohol intake \- greater than 21 units per week in men and greater than 14 in women
- •2\. A further liver disease diagnosis
- •3\. Poorly controlled diabetes \- HbA1c greater than 8\.0%
- •4\. Pregnancy
- •5\. Cirrhosis
- •6\. Significant inflammation on liver biopsy \- classified as a Brunt moderate or severe
- •7\. Life expectancy of less than 2 years
- •8\. Contraindications to MR scanning \- pacemaker or metallic foreign body
- •9\. Changes in the dose or initiation of lipid altering medication within the preceeding three months, such as statins, fibrates or systemic steroids
- •10\. Use of n\-3 PUFA supplements within the prior 4 months, an adequate washout period
Outcomes
Primary Outcomes
Not specified
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