Absorption of Amoxicillin tablets in overweight volunteers

Not Applicable

• Conditions: Obesity; C18.654.726.500

• Registration Number: RBR-4n2c59
• Lead Sponsor: Hospital Universitário Regional de Maringá

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-10-14
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Volunteers with obesity according to the classification proposed by the World Health Organization (BMI 30 to 40 kg / m²); being between 18 and 50 years old; have signed the consent form.

Exclusion Criteria

Intolerance or hypersensitivity to Amoxicillin and other antibiotics of the class; kidney or liver failure; pregnancy; breast-feeding; users of alcohol or illicit drugs; use of prokinetics (metoclopramide, erythromycin or domperidone); participation in clinical study in the last 3 months; have thrombocytopenia, anemia, heart disease, diabetes and / or hypertension, and endocrine disorders; being under 18 years old and over 50 years old; volunteers with difficulty in swallowing and / or presenting fistulas, significant stenosis or obstruction

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Statistically significant difference (p <0.05) in the pharmacokinetic parameters of Amoxicillin between the obese and eutrophic group, which will be calculated from the concentration versus time curve.

Secondary Outcome Measures

Name	Time	Method
Statistically significant difference (p <0.05) in pharmacokinetic parameters of Amoxicillin in the obese and eutrophic group when compared with literature data.