The safety of therapeutic hypothermia for acute encephalitis / encephalopathy among pediatric patients
- Conditions
- Acute encephalitis and encephalopathy among pediatric patients
- Registration Number
- JPRN-UMIN000019510
- Lead Sponsor
- Department of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Not provided
Because coagulopathy are common during hypothermia, (1-1) Intracranial hemorrhage was seen on head CT or MRI, (1-2) Hemorrhagic diathesis, or (1-3) thrombocytopenia less than 50,000/mm3. Because immunosuppression are common during hypothermia, (2-1) Congenital immunologic disability (SCID, a-gamma-globurinemia, chronic granulomatous disease, et.al). Because circulation are easily suppressed during hypothermia, (3-1) Cardiac disease or arrhythmia, which need medication. (3-2) Decreased cardiac contractility (LVEF < 40% on echocardiogram) (3-3) Normal blood pressure is not maintainable even with catecholamines or vasopressors. Because this study needs informed consent from legal representatives, (4-1) When legal representatives denied to be participated, (4-2) When child abuse is strongly suspected, Or whenever the regarding physicians thought the patient is not suitable for this study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method