Evaluation of the Role of the Intestinal Microbiota in the Mechanism of Postoperative Ileum After Colorectal Surgery : a Preliminary Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Composition of the feces microbiota before surgery
研究概览
简要总结
Postoperative ileus (POI) after colorectal surgery is frequent and is a burden for national health authority because it increases the morbidity and the length of hospital stay.
Some of the stage of the mechanism of POI are known and are now targeted to reduce its occurence but despite these measures, POI still happens in 10-30% of surgeries.
The role of the intestinal microbiota in POI is unknown while it could be a new target to reduce its duration or its occurence.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •laparoscopic colorectal resection with anastomosis and without diverting stoma
排除标准
- •risk of modification of the microbiota (terminal enterostomy, chronic inflammatory bowel disease, oesophageal or gastric surgery, vagal nerves lesion, beta lactamin allergy, bowel cleansing)
- •postoperative complication
结局指标
主要结局
Composition of the feces microbiota before surgery
时间窗: within the 2 last days before surgery
The composition of the microbiota will be assessed by the analysis of the region V3 V4 of the 16S rRNA, amplificateur by high flow sequencing
Composition of the feces microbiota after surgery
时间窗: up to the first postoperative stools, an average of 3 postoperative days
The composition of the microbiota will be assessed by the analysis of the region
次要结局
未报告次要终点