Intestinal Microbiota and Postoperative Ileus After Colorectal Surgery
- Conditions
- Postoperative IleusSurgery-Complications
- Registration Number
- NCT05512741
- Lead Sponsor
- University Hospital, Angers
- Brief Summary
Postoperative ileus (POI) after colorectal surgery is frequent and is a burden for national health authority because it increases the morbidity and the length of hospital stay.
Some of the stage of the mechanism of POI are known and are now targeted to reduce its occurence but despite these measures, POI still happens in 10-30% of surgeries.
The role of the intestinal microbiota in POI is unknown while it could be a new target to reduce its duration or its occurence.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 64
- laparoscopic colorectal resection with anastomosis and without diverting stoma
- risk of modification of the microbiota (terminal enterostomy, chronic inflammatory bowel disease, oesophageal or gastric surgery, vagal nerves lesion, beta lactamin allergy, bowel cleansing)
- postoperative complication
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composition of the feces microbiota before surgery within the 2 last days before surgery The composition of the microbiota will be assessed by the analysis of the region V3 V4 of the 16S rRNA, amplificateur by high flow sequencing
Composition of the feces microbiota after surgery up to the first postoperative stools, an average of 3 postoperative days The composition of the microbiota will be assessed by the analysis of the region
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Angers University Hospital, visceral and endocrine surgery department
🇫🇷Angers, France
Angers University Hospital, visceral and endocrine surgery department🇫🇷Angers, France