Intestinal Microbiota and Postoperative Ileus After Colorectal Surgery

Recruiting

• Conditions: Postoperative Ileus; Surgery-Complications
• Interventions: Other: Feces collection

• Registration Number: NCT05512741
• Lead Sponsor: University Hospital, Angers

Brief Summary

Postoperative ileus (POI) after colorectal surgery is frequent and is a burden for national health authority because it increases the morbidity and the length of hospital stay.

Some of the stage of the mechanism of POI are known and are now targeted to reduce its occurence but despite these measures, POI still happens in 10-30% of surgeries.

The role of the intestinal microbiota in POI is unknown while it could be a new target to reduce its duration or its occurence.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-08-10
• Study First Submitted QC: 2022-08-20
• Study First Posted: 2022-08-23
• Study Start: 2022-10-21
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-08
• Last Update Posted: 2024-01-11
• Primary Completion: 2024-11
• Study Completion: 2024-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• laparoscopic colorectal resection with anastomosis and without diverting stoma

Exclusion Criteria

• risk of modification of the microbiota (terminal enterostomy, chronic inflammatory bowel disease, oesophageal or gastric surgery, vagal nerves lesion, beta lactamin allergy, bowel cleansing)
• postoperative complication

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
No POI group	Feces collection	Patients that do not experience POI. The 10 patients having the fastest recovery of gastro-intestinal functions after surgery during the period of inclusion will be included in the study
Group Ileus	Feces collection	Patients that experience POI after colorectal surgery. POI is defined by the presence of 2 of the 5 criteria of Vather from the first postoperative day. The first 10 consecutive patients experiencing POI will be included in the study.

Primary Outcome Measures

Name	Time	Method
Composition of the feces microbiota before surgery	within the 2 last days before surgery	The composition of the microbiota will be assessed by the analysis of the region V3 V4 of the 16S rRNA, amplificateur by high flow sequencing
Composition of the feces microbiota after surgery	up to the first postoperative stools, an average of 3 postoperative days	The composition of the microbiota will be assessed by the analysis of the region

Trial Locations

Locations (1)

Angers University Hospital, visceral and endocrine surgery department; 🇫🇷 Angers, France