Comparison of scalp nerve block and local anaesthetic infiltration with local anaesthetic infiltration alone on inflammatory response in patients undergoing elective neurosurgery.

This study is randomised ,comparative, prospective ,interventional study where we are comparing effect of scalp nerve block and local anaesthetic infiltration in one group and in other group only the effect of local anaesthetic infiltration alone will be studied on inflammatory response in patients undergoing elective neurosurgery under general anaesthesia by means of bio markers like c reactive protein , interleukin 6 and interleukin 10 as the primary outcome. Secondary outcome will be studied from hemodynamic stability by means of heart rate and blood pressure and comparing postoperative pain by means of visual analog scale.

In this study with this parameters , we are hypothesising that scalp nerve block and local anaesthetic infiltration together are  superior to local anaesthetic infiltration alone in controlling inflammatory response , maintaining hemodynamic stability and relieving postoperative pain.Primarily inflammatory response will be measured  by means of c recative protein , interleukin 6 and interleukin 10  first as baseline then immediately in postoperative period then at 24 hours of surgery  , secondarily hemodynamic stability measured by means of heart rate and blood pressure before anaesthesia induction, 5 minutes after skin incision, during dura opening,at the end of surgery and postoperative pain compared immediately in postoperative period and at 12 hours of surgery.