The effect of intravenous sedation on the lower oesophageal sphincter: A comparison between dexmedetomidine and remifentanil in healthy adult volunteers.

Phase 3

• Conditions: Aspiration Risk during sedation; Reflux and sedation; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12611000794909
• Lead Sponsor: Dr Islam Elhalawani

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-07-28
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Healthy volunteers

Exclusion Criteria

(i)Inability to give informed consent
(ii)Pregnancy or breast feeding
(iii)Previous gastrointestinal surgery (apart from appendicectomy)
(iv)medications known to affect gastrointestinal motility (erythromycin, metoclopramide and domperidone)
(v)Clinically diagnosed gastro-oesophageal reflux disease and on acid suppression therapy
(vi)Current use of opiates or any sedatives
(vii)History of cardiac disease
(viii)History of lung disease
(ix)Smoking
(x)Kidney disease
(xi)Liver disease
(xii) diabetes
(xiii)Known allergy to anaesthetic drugs or any reported difficulties during previous anaesthesia
(xiv)BMI > 33

Study & Design

• Study Type: Interventional
• Study Design: Not specified