Blood Pressure Effects of egg white hydrolysate consumed by Untreated Hypertensive Subjects

Recruiting

• Registration Number: NL-OMON21860
• Lead Sponsor: Bio-Actor BVBATechnologiepark 39052 GentBelgium

Brief Summary

A. Dávalos et.al., Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis, J. Food Prot (2004), 67 (9) 1939-1944. <br> <br> Miguel. M. et.al., Short-term effect of egg-white hydrolysate products on the arterial blood pressure of hypertensive rats. Br J Nutr. (2005), 94(5):731-7.<br> <br> Miguel, M. et.al., Long-term intake of egg white hydrolysate attenuates the development of hypertension in spontaneously hypertensive rats, Life Sci., (2005), Dec. 27.<br> <br> Miguel, M. et.al., Effect of simulated gastrointestinal digestion on the antihypertensive properties of ACE-inhibitory peptides derived from ovalbumin, J Agric Food Chem., (2006), 54(3), 726-731.<br> <br> Miguel, M. et.al., Vasodilatory effects of peptides derived from egg white proteins, Regulatory peptides, (2007), 140, 131-135.<br> <br> Miguel, M. et.al., Angiotensin-converting enzyme activity in plasma and tissues of spontaneously hypertensive rats after short- and long-term intake of hydrolysed egg white, Mol. Nutr. Food Res. (2007), 51, 555-563<br> <br> Miguel, M. et.al. Antihypertensive, ACE-inhibitory and vasodilator properties of an egg white hydrolysate: effect of a simulated intestinal digestion, Food Chemistry (2007), 104, 163-168

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

1. Blood pressure >130 mm Hg (systolic) and >80 mm Hg (diastolic)

2. Not taking any concomitant medication

Exclusion Criteria

1. Participation in any other clinical trial including blood sampling and/or administration of substances up to 90 days before day 1 of this study.

2. Mental status that is incompatible with the proper conduct of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To establish a significant blood pressure reduction by providing subjects with supplements of an egg white hydrolysate.

Secondary Outcome Measures

Name	Time	Method
Effect on serum cholesterol levels