NL-OMON52444尚未招募不适用
Testicular biopsies in young boys diagnosed with cancer to preserve future fertility- towards a safe and feasible autologous cell therapy in future. - PRINCE project
Prinses Máxima Centrum voor kinderoncologie0 个研究点目标入组 100 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •-Young patients with malignancies treated with alkylating agents (CED
- •>4000mg/m2), brain tumours treated with cranio-(spinal) irradiation and
- •alkylating agents, total body irradiation, pelvic irradiation, testicular
- •irradiation, and conditioning for stem cell transplantation. The boys and
- •parents will be given an individual estimate on the probability of infertility
- •in relation to their scheduled treatment.
- •-Only if parents/legal guardians have signed consent. And in case boys > 12
- •years informed consent will be signed together with the informed consent of
- •their parents
- •-For follow up all boys included in the previous cohort at the Amsterdam UMC,
- •location AMC who have undergone a testicular biopsy prior to start of
- •chemotherapy during the period 2011-2018.
排除标准
- •Malignancies located in the testis, history of bilateral cryptorchidism or
- •testicular torsion, ability to ejaculate vital spermatozoa on masturbation or
- •electro-stimulated ejaculation. Previous history or increased risk for
- •pre-existing (congenital) gonadal insufficiency or known chromosomal
- •abnormalities that affect male fertility.
研究者
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