Research on improvement mechanism of solar lentigo
- Conditions
- Solar lentigo
- Registration Number
- JPRN-UMIN000052132
- Lead Sponsor
- Jieikai Byoin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- Female
- Target Recruitment
- 120
Not provided
(1) Persons who have skin symptoms such as external wound, rosacea, eczema, etc. at the evaluation site (2) Persons who regularly go or plan to go to tanning salons during the study period (3) Persons who are likely to be exposed to significant sunlight during the study period (e.g., Daily exercise during the daytime) (4) Persons with a history of atopic dermatitis (5) Persons who are expected to suffer from severe hay fever* during the study period (*level requiring a hospital visit) (6) Persons with a history of severe hepatic disorder, renal disorder, or myocardial infarction (7) Persons with severe anemia (8) Persons with a keloid constitution (scars easily become red and swollen and are difficult to heal) (9) Persons who have diabetes mellitus (10) Persons who are taking antithrombotic medicines (11) Pregnant, lactating mothers and those who plan to become pregnant during the study period (12) Persons who are currently participating in other clinical studies or who plan to participate in other clinical studies during the study period (13) Persons with cold symptoms or fever of 37.5 degrees Celsius or higher (Exclusion criteria only on the day of the visit; temperature will be checked at the reception desk) (14) Persons who are taking or have taken gold preparations (Shiosol, Auranofin,etc.) for rheumatism, etc (15) Persons who have gold threads or metal plates, etc. inserted in the treatment area (face) (16) Persons who have skin-colored tattoos on the treatment area (face) (17) Persons who have undergone cosmetic surgery in the past and are currently in downtime (18) Persons who have experienced severe pain, erythema, or scarring after undergoing cosmetic surgery in the past (19) Persons who have experienced rashes or skin problems due to hair dye (20) Others whom the doctors involved in the research deem inappropriate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method # Analysis of relationship between skin color change and gene expression at each measurement point. # Differences in gene expression changes among treatments.
- Secondary Outcome Measures
Name Time Method # Differences in gene expression between groups with and without improvement of solar lentigo. # Analysis of relationship between gene expression and hyperpigmentation except solar lentigo in the medical treatment group.