Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma

Not Applicable

• Conditions: Exercise Induced Bronchospasm
• Interventions: Diagnostic Test: Eucapnic voluntary hyperventilation; Diagnostic Test: Exercise challenge on a cycle ergometer

• Registration Number: NCT03063424
• Lead Sponsor: Université de Sherbrooke

Brief Summary

The diagnosis of exercise-induced bronchospasm (EIB) is difficult. The metacholine challenge test is not enough specific for the diagnosis of EIB. The exercise challenge test on a cycle ergometer is often use to diagnose this condition. This test has very high specificity, but not enough sensibility because the ventilation achieved during this test is often not big enough to induce a bronchospasm, especially in trained athletes. Eucapnic voluntary hyperventilation (EVH) is the recommended test of the Olympic National committee to establish the diagnosis of EIB, but there are no study comparing the sensibility and specificity of the cycle ergometer challenge test and the isocapnic hyperventilation in an establish population of asthmatics. The investigators assume that the sensitivity and specificity of EVH are higher than those of the cycle ergometer for the diagnosis of EIB in a population of asthmatics with symptoms suggestive of bronchospasm on exertion. In a population of asthmatics with exercise symptoms, what is the sensitivity and specificity of EVH and exercise challenge on a cycle ergometer for the diagnosis of EIB?

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06
• Study First Submitted: 2017-01-22
• Study First Submitted QC: 2017-02-20
• Study First Posted: 2017-02-24
• Status Verified: 2019-06
• Last Update Submitted: 2019-06-01
• Last Update Posted: 2019-06-04
• Primary Completion: 2019-10
• Study Completion: 2019-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

• Pregnant or breast-feeding women.
• The subject should not suffer from clinically significant concomitant diseases that may compromise the course of the study.
• The subject should not have taken per os or intravenously steroids in the 8 weeks prior to the study.
• The subject should not have experienced significant symptoms of respiratory tract infection (viral or bacterial) in the 8 weeks prior to the study.
• The subject must not have participated in another study during the month preceding the date of enrollment of this study.
• The subject should not have smoked within the last 6 months.

Exclusion criteria during the study:

• The subject doesn't show up for all 3 visits or doesn't complete all required exams.
• The subject develops a respiratory tract infection, an acute exacerbation of his asthma or any other conditions that compromise his participation in the required examinations.
• The subject has a pre-test FEV1 of less than 80%.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Healthy subjects	Eucapnic voluntary hyperventilation	-
Asthmatics with EIB	Exercise challenge on a cycle ergometer	-
Healthy subjects	Exercise challenge on a cycle ergometer	-
Asthmatics with EIB	Eucapnic voluntary hyperventilation	-

Primary Outcome Measures

Name	Time	Method
Compare the sensitivity and specificity of eucapnic voluntary hyperventilation versus exercise challenge testing on a cycle ergometer for exercise-induced bronchospasm diagnosis in established asthmatic subjects with exercise symptoms.	through study completion, an average of 1 month

Secondary Outcome Measures

Name	Time	Method
Correlate the magnitude of exercise bronchoconstriction during EVH and exercise challenge testing on a cycle ergometer (measurement of FEV1 before and after these tests) with severity of symptoms of EIB (with questionnaires)	through study completion, an average of 1 month	The questionnaires for the severity of symptoms of EIB will include a modified Borg questionnaire, symptoms of EIB after the tests and usual symptoms of EIB after a vigorous effort.
Correlate the magnitude of exercise bronchoconstriction during EVH and exercise challenge testing on a cycle ergometer (FEV1 before and after these tests) with severity of bronchial hyperreactivity evaluated by methacholine challenge test (MCT).	through study completion, an average of 1 month	severity of bronchial hyperreactivity evaluated by methacholine challenge test (MCT) will be measured with the provocative concentration causing a 20% fall in FEV1 (PC20) (mg/ml) as recommended by the American Thoracic Society (ATS).

Trial Locations

Locations (1)

Université de Sherbrooke; 🇨🇦 Sherbrooke, Quebec, Canada