Pharmacokinetics of single-dose administration of paracetamol by nasoduodenal tube throughout childhood

• Conditions: Pijn of koorts waarbij paracetamol gegeven wordt via de duodenale sonde bij kinderen; fever; Pain

• Registration Number: NL-OMON45360
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

parenteral informed consent (children 12-18 years of age also informed consent from themselves)
age 0-18 years of age
arterial or venous line
receiving paracetamol through duodenal tube

Exclusion Criteria

no informant consent
no ongoing enteral feeding through the nasoduodenal tube
no baseline paracetamol sample has been taken before the paracetamol dosage

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>concentration-time profiles of paracetamol. The study parameters will be<br /><br>primary PK parameters (clearance and volume of distribution)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>