Comparison between the effect of Simvastatin and Atorvastatin in controlling post cardiac surgery depression.

Phase 2

• Conditions: Depression.; Moderate depressive episode

• Registration Number: IRCT201410271556N68
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Patients who have undergone coronary bypass surgery.
2. Patients who based on DSM-IV have major depression and based Hamilton rating scale for depression (Ham-D 17 items) their score is => 18.
3. No psychiatric symptoms
4. Not receiving psychotropic drugs
5. Not receiving antidepressants during the last month
6. Do not receiving ECT during the last two months
7. No thyroid problem
8. Age between 15 and 80 years
9. No liver dysfunction
10. No Muscular disorders
11. Not receiving other antilipid drugs
12. No hypersensitivity to statins
13. LDL => 80
14. Liver enzymes not being elevated at the time of recruitment
15. No life threatening disease
16. No neurological disorders
17. Not being pregnant
18. No breast feeding
19. Giving informed consent

Exclusion criteria:
1. Existing other disorders rather than depression, including Bipolar disorders, Schizophrenia, and other psychotic disorders
2. History of drug abuse or dependency within the last three months
3. Probability of suicide or its tendency during the last year
4. Women who are going to be pregnant within the next few months
5. Women who use OCP for pregnancy prevention
6. Patients who have received antidepressants during the last month
7. Patients who have received ECT withing the last two months
8. Patients who need un-usual psychiatric treatments
9. Patients with liver dysfunction
10. Muscular disorders
11. Receiving other antilipid drugs
12. Hypersensitivity to statins
13. LDL < 80
14. Elevated liver enzymes at the time of recruitment
15. Life threatening diseases
16. Neurological diseases

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression. Timepoint: At the starting time, two weeks after intervention, four weeks after intervention, and six weeks after intervention. Method of measurement: Hamilton Depression Questionnaire.

Secondary Outcome Measures

Name	Time	Method
Drugs side effects. Timepoint: First week after starting the study, second week after starting the study, fourth week after starting the study, and sixth week after starting the study. Method of measurement: Drug side effects checklist.