Prospective clinical study to confirm and extend the correlation between HSD11B1 polymorphisms, bone mineral density, and cortisol metabolism in patients with osteoporosis

Recruiting

• Conditions: M80; M81; M82; E10; E11; E12; E13; E14; E78; F32

• Registration Number: DRKS00016601
• Lead Sponsor: niversitätsmedizin Göttingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

> 20% increased 10-year fracture risk

Exclusion Criteria

glucocorticoid therapy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association of HSD11B1 SNP genotypes with BMD (bone mineral density) and PDC (post dexamethasone cortisol)

Secondary Outcome Measures

Name	Time	Method
Muscle function: Timed-up and go, chair rising, grip strength measurement; Metabolism: LDL cholesterol, HbA1c; Depression: Questionnaire (HADS Score); Bone quality: Trabecular Bone Score (TBS)