EUCTR2005-005775-15-IT进行中（未招募）不适用
Pilot phase II study of a combined immunotherapy protocol based on oral vaccination and direct intratumoral injection of Salmonella Typhi Ty21a Vivotif in metastatic cutaneous melanoma patients. - ND
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 43
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •stage III and IV M1A melanoma patients with at least three non resectable superficial metastatic lesions, aged at least 18 years with HLA-A 0201 allele; adequate bone-marrow reserve, renal and hepatic functions and cardiac function.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Principal exclusion criteria presence of visceral metastases; relevant medical history including primary or secondary immune deficiencies or known significant autoimmune disease, serious cardiac, gastrointestinal, hepatic or pulmonary disease which would reduce life expectancy to 5 years, coagulation disorders, other malignancies within 5 years and need for immunosuppressants.
研究者
相似试验
已完成
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The phase I study of the combined immunotherapy using alpha-galactosylceramide pulsed antigen presenting cells and tumor-specific peptide pulsed dendritic cells for patients with advanced head and neck mucosal melanomaHead and neck mucosal malignant melanomaJPRN-UMIN000011508Department of Otorynolaryngology, Head and Neck Surgery9
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不适用
Patients who suffer from T-Prolymphocytic leukemia and have received none or one chemotherapy so far will be treated with Fludarabine, Cyclophosphamide, Mitoxantrone and Alemtuzumab.ntreated patients with T-prolymphocytic leukemia (T-PLL) according to WHO criteria or pretreated patients (max. one previous treatment) with T-PLL .EUCTR2008-001421-34-DEniversity of Cologne, Sponsor-Quality Management16
进行中（未招募）
不适用
Patients who suffer from T-Prolymphocytic leukemia and have received none or one chemotherapy so far will be treated with Fludarabine, Cyclophosphamide, Mitoxantrone and Alemtuzumab.ntreated patients with T-prolymphocytic leukemia (T-PLL) according to WHO criteria or pretreated patients (max. one previous treatment) with T-PLL.EUCTR2008-001421-34-ATniversität zu Köln16