Glutathione Metabolism in Neonates

Not Applicable

Completed

• Conditions: Glutathione (GSH) deficiency; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN82896385
• Lead Sponsor: Sophia Foundation For Scientific Research (SSWO) (Netherlands)

Brief Summary

2009 results in https://pubmed.ncbi.nlm.nih.gov/19822595/ (added 18/02/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-12-20
• Study Completion: 2007-08-11
• Last Update Posted: 1 March 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Preterm infants with birth weights less than 1500 g and term infants. Infants in both groups should have arterial catheters for the purpose of obtaining blood samples.

Exclusion Criteria

1. Known congenital abnormalities
2. Chromosome defects
3. Metabolic disease
4. Endocrine, renal, or hepatic disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glutathione synthesis rate, measured at day 2 post-natal

Secondary Outcome Measures

Name	Time	Method
<br> 1. Concentration of oxidative stress markers, Apgar Score, oxygen saturation and heart rate in first 20 minutes after birth, measured on day 1 and day 7<br> 2. Mortality<br> 3. The incidence of bronchopulmonary dysplasia<br>