Dose-response Enteral Citrulline for Normal Healthy Volunteers and Surgery Patients

Not Applicable

Completed

• Conditions: Nutritional Deficiency
• Interventions: Other: citrulline; Other: Lemonade

• Registration Number: NCT00950976
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

To determine the level of citrulline to produce a given amount of arginine in healthy volunteers and surgical patients. Arginine-related amino acids are expected to increase as a result of increased substrate provided by citrulline.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2009-07-10
• Study First Submitted QC: 2009-07-30
• Study First Posted: 2009-08-03
• Primary Completion: 2010-04
• Study Completion: 2010-08
• Status Verified: 2012-04
• Last Update Submitted: 2012-04-24
• Last Update Posted: 2012-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• adults, male & female, non-pregnant
• BMI 18.5-29.9

Exclusion Criteria

• cancer
• HIV positive

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Citrulline	citrulline	-
lemonade	Lemonade	Equal volume and flavor to citrulline.

Primary Outcome Measures

Name	Time	Method
Plasma amino acid levels	8 hours

Trial Locations

Locations (1)

University of Pittsburgh Medical Center; 🇺🇸 Pittsburgh, Pennsylvania, United States