Comparative evaluation of hydroxyapatite nanoparticles with and without herbal gel in the treatment of periodontal intrabony osseous defects: A Clinico-Radiographic Study
试验速览
- 阶段
- Phase 3 4
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- To evaluate and compare the efficacy of hydroxyapatite nanoparticles with and without herbal gel in the treatment of periodontal intrabony osseous defects, clinically and radiographically by CBCT.
研究概览
简要总结
Comparative evaluation of hydroxyapatite nanoparticles with and without herbal gel in the treatment of periodontal intrabony osseous defects: A Clinico-Radiographic Study
Periodontitis is a polymicrobial disease where the inflammatory process results in progressive tissue destruction. Destructive periodontitis caused by bacterial plaque involves resorption of alveolar bone supporting the teeth. The ultimate goal of periodontal therapy is to arrest the disease progression and to promote the regeneration of the lost tissues. A synthetic nanocrystalline hydroxyapatite (NHA) paste, containing 65% water and 35% nanostructured apatite particles has been introduced for augmentation procedures in osseous defects. Advantages of this material are the close contact with surrounding tissues, quick resorption characteristics, and the large number of molecules on the surface. There are many natural or herbal powders in research for their benefits over synthetic materials. This high popularity in applying complementary and alternative medicine can be due to its advantages such as widespread availability, no or fewer side effects, moderate efficacy, and low cost as compared with synthetic drugs. Kepok banana peel (Musa paradisiaca linn. Kepok) contains active ingredients such as Âavonoids, tannins, saponins, and gallocatechinese. These active ingredients possess antioxidant, antibacterial, anti-inflammatory and analgesic activities. Bromelain, an extract derived from Ananas comosus (popularly known as pineapple), contains proteinases that exhibits anti-inflammatory properties. To our knowledge the current randomized clinical trial is the first to explore the adjunctive effect of combining herbal gel with hydroxyapatite nanoparticles in the surgical treatment of intraosseous bony defects by Cone Beam Computed Tomography (CBCT). So, this study is designed to evaluate and compare the efficacy of hydroxyapatite nanoparticles with and without herbal gel in the treatment of periodontal intrabony osseous defects by CBCT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with stage III periodontitis assessed by probing pocket depth (PPD) ≥ 6mm, interdental clinical attachment loss (CAL) ≥ 5mm.
- •Patients with two or three wall intraosseous defects in either maxillary or mandibular arch or interarch.
排除标准
- •Patients with history of systemic diseases, allergy or drug usage.
- •Patients who have undergone periodontal treatment in previous 6 months.
- •Pregnant or lactating women.
- •Smokers, tobacco chewers and patients with poor oral hygiene index will be excluded from the study.
- •In addition, tooth with caries, mobility greater than grade II will be excluded.
结局指标
主要结局
To evaluate and compare the efficacy of hydroxyapatite nanoparticles with and without herbal gel in the treatment of periodontal intrabony osseous defects, clinically and radiographically by CBCT.
时间窗: Baseline, 3 months and 6 months.
次要结局
- 1) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intraosseous bony defects when treated with herbal gel with hydroxyapatite nanoparticles at baseline, 3 months and 6 months post operatively.(2) To assess Clinical attachment loss (CAL), probing pocket depth (PPD) in intraosseous bony defects when treated with hydroxyapatite nanoparticles at baseline, 3 months and 6 months postoperatively.)
研究者
Dr. Surekha Rathod
Ranjeet Deshmukh Dental College and Research Centre, Nagpur.