The Role of Nebulized Budesonide in the Treatment of Acute Exacerbations of COPD

Terminated

• Conditions: COPD Acute Exacerbation

• Registration Number: NCT00274222
• Lead Sponsor: Inonu University

Brief Summary

This study was designed to evaluate the hypothesis that nebulized budesonide) might be an alternative to systemic corticosteroids (SC) in the treatment of patients with acute exacerbations of COPD (AECOPD).

Detailed Description

Patients, hospitalized with AECOPD, were randomized into three groups. Group I received only bronchodilator treatment (BDT), Group II received SC (40 mg prednisolon) plus BDT, and Group III received nebulized budesonide (NB)(1500 mcg qid) plus BDT. Improvement rates in multiple parameters during 10-day hospitalization, and acute exacerbation and re-hospitalization rates within one-month after discharge were compared between the groups.

Study Timeline

• Study Start: 2003-01
• Study Completion: 2005-10
• Status Verified: 2006-01
• Study First Submitted: 2006-01-09
• Study First Submitted QC: 2006-01-09
• Last Update Submitted: 2006-01-09
• Study First Posted: 2006-01-10
• Last Update Posted: 2006-01-10

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• COPD patients who were admitted to our pulmonary department for an acute exacerbation were prospectively enrolled in the study

Exclusion Criteria

• COPD patients hospitalized with specific reasons like pneumonia, pulmonary emboli, congestive heart failure, pneumothorax etc. as the cause of acute exacerbation, or patients with risk of imminent respiratory failure requiring mechanical ventilation or direct admission to the ICU were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified