Patient Characteristics, Outcome and Thromboembolic Events Among Adult Critically Ill COVID-19 Patients With Different Anticoagulant Regimes at One of the Biggest Emergency Hospitals in Northern Europe, Sweden
Overview
- Phase
- Not Applicable
- Intervention
- Dose of Tinzaparin or Dalteparin
- Conditions
- Covid-19
- Sponsor
- Karolinska Institutet
- Enrollment
- 166
- Locations
- 1
- Primary Endpoint
- 28-days ICU mortality
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aims of the study are to to associate anticoagulation (AC) regime with outcome in critically ill patients with Covid-19. This will be done by describe baseline characteristics and comorbidities before hospital admission, level of organ support and dose of AC treatment and associate this with 28 days survival, survival outside ICU, thromboembolic event and bleeding complications.
Investigators
Christer Svensen
Professor
Karolinska Institutet
Eligibility Criteria
Inclusion Criteria
- •laboratory confirmed positive test for SARS-CoV-2
- •admitted to ICU because of critical illness due to covid-19
Exclusion Criteria
- •patients with treatment for thromboembolic complications at arrival to the ICU
- •short ICU length of stay defined as discharged the same or the following day as ICU admission
Arms & Interventions
thrombose prophylaxis
The dose used to prevent thromboembolic complication in critically ill
Intervention: Dose of Tinzaparin or Dalteparin
double thrombose prophylaxis
Double the dose used to prevent thromboembolic complication in critically ill
Intervention: Dose of Tinzaparin or Dalteparin
full dose anticoagulant
Dose used to treat thromboembolic event
Intervention: Dose of Tinzaparin or Dalteparin
Outcomes
Primary Outcomes
28-days ICU mortality
Time Frame: 28 days from ICU-admission
28-days ICU mortality from admission to the ICU. Discontinue of ICU-care to palliative care counts as death.
Secondary Outcomes
- Incidence of thromboembolic events(28 days from ICU-admission)
- Incidence of bleeding events(28 days from ICU-admission)
- ICU-free days alive from ICU-admission.(28 days from ICU-admission)