NCT03342235撤回不适用
Excimer Laser Surgery for Anisometropic Amblyopia
Jaeb Center for Health Research0 个研究点开始时间: 2020年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- Mean Change in Best Corrected Visual Acuity in the Amblyopic Eye
研究概览
简要总结
Study Objectives To compare the efficacy and safety of surgical treatment (PRK) versus non-surgical treatment of anisometropic amblyopia in children who have failed conventional treatment due to non-compliance or non-response.
Synopsis of Study Design
The study consists of two phases:
- A Patching Run-In Phase during which all participants are treated for at least 8 weeks with continued refractive correction (with spectacles and/or contact lenses) and patching prescribed 42 hours per week (averaging 6 hours daily) until no further improvement over 2 consecutive visits at least 4 weeks apart or the vision no longer meets eligibility criteria.
- A Randomized Trial Phase, beginning after no further VA improvement in the patching run-in phase and qualifying amblyopia is still present, during which the participant is assigned to either surgery with PRK and patching prescribed 2 hours per day or to non-surgical treatment with continued refractive correction (with spectacles and/or contact lenses) and patching prescribed 2 hours per day.
详细描述
The study is evaluating the efficacy of surgical treatment with PRK versus non-surgical treatment of anisometropic amblyopia in children who have failed conventional treatment. The primary analysis will be a treatment group comparison of the change in BCVA in the amblyopic eye at the 8-month primary outcome visit. For participants wearing a contact lens, the BCVA will be the visual acuity tested in the contact lens rather than in spectacles (or trial frames).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 3 Years 至 7 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 3 to <8 years
- •Best-corrected amblyopic-eye VA using the ATS single-surround HOTV letter protocol (ATS-HOTV) meeting the following criteria:
- •If age 3 to <5 years, 20/80 to 20/800 (a re-test is required if the VA is 20/80)
- •If age 5 to <8 years, 20/63 to 20/800 (a re-test is required if the VA is 20/63)
- •Note: For participants who require a re-test (as specified above), the better of the test and re-test acuities must meet the eligibility criteria for the amblyopic eye and will serve as the enrollment VA.
- •Best-corrected fellow-eye VA meeting the following criteria by ATS-HOTV:
- •If age 3 years, 20/50 or better
- •If age 4 to 5 years, 20/40 or better
- •If age 6 to 7 years, 20/32 or better
- •Best-corrected inter-ocular acuity difference ≥ 3 logMAR lines by ATS-HOTV
- •Refractive error meeting the following criteria (based on a cycloplegic refraction that is not more than 4 months old):
- •Refractive error in the amblyopic eye must be greater than the fellow eye.
- •If the amblyopic eye is myopic, SE refractive error in the amblyopic eye between -3.00D and -12.00D, inclusive.
- •If the amblyopic eye is hyperopic, SE refractive error in the amblyopic eye between +3.00D and +6.00D, inclusive, if <=1.00D of astigmatism in the amblyopic eye; and between +3.00D and +5.00D, inclusive, if >1.00D of astigmatism in the amblyopic eye.
- •Astigmatism less than or equal to 3.50D in the amblyopic eye.
- •SE refractive error in the fellow eye between -4.00D and +3.00D, inclusive, with no astigmatism limits.
- •For participants 3 to <5 years of age, at least 5.00D of SE anisometropic difference between the two eyes by cycloplegic refraction; for subjects 5 to <8 years of age, at least 3.00D SE anisometropic difference
- •No more than 3.00D of difference in cylinder power between the two eyes
- •Target postoperative refractive error (if participant becomes eligible for randomization) must be achievable with PRK as defined in Table 3 and must be within 2.00D of the fellow eye.
- •Prior to enrollment into the Patching Run-In Phase, must have had patching and/or optical penalization with atropine or Bangerter filters prescribed for at least 6 months and optical correction of refractive error prescribed for at least 6 months. Prior treatment does not have to be continuous. Compliance with prescribed treatment does not influence eligibility but the best effort at compliance is expected from both the patient and provider.
- •Corneal thickness >500 microns (>510 microns within the previous 7 months, or corneal thickness between 500 and 510 microns within the last 2 months).
- •Central corneal thickness must be enough to allow the treatment dose needed while leaving a residual corneal thickness of ≥ 375 microns.
- •IOP ≤ 22 mm Hg within 7 months of enrollment
- •Investigator believes that the participant has achieved maximum improvement in amblyopic-eye VA with conventional treatment.
- •Investigator is willing to prescribe patching, and parent and child are willing to attempt patching for at least 8 weeks for 42 hours per week (averaging 6 hours daily) in the Patching Run-In Phase.
- •No rigid gas permeable lens (including OrthoK) worn in the past 2 months
- •Soft contact lens is currently worn, has been attempted within the past 4 months, or a contact lens fitting exam (paid for by the study) is scheduled or the investigator does the contact lens fitting on the same day as enrollment.
- •Parent understands the protocol and is willing to accept randomization (if child meets eligibility criteria after Patching Run-In Phase).
- •Parent has a phone (or access to phone) and is willing to be contacted by Jaeb Center staff or other study staff during the next 36 months.
- •Relocation outside of area of an active PEDIG site for this study without the next 36 months is not anticipated.
排除标准
- •Non-refractive ocular cause for reduced VA in the amblyopic eye (example: cataract, posterior staphyloma, extensive myelinated nerve fiber layer, optic nerve anomaly, macular scar, corneal opacity); or any cause of previous form deprivation.
- •Prior penetrating ocular surgery or injury
- •Prior strabismus surgery within 60 days preceding enrollment
- •Diagnosis of collagen vascular disease, Marfan syndrome, Ehlers-Danlos syndrome or other disorder of collagen synthesis
- •Previous ocular condition that may predispose the eye to be treated for future complications, for example:
- •Corneal disease (e.g., herpes simplex, herpes zoster keratitis, keratoconus or suspicion of keratoconus based upon family history, slit lamp exam, retinoscopy, or corneal topography (if able), recurrent erosion syndrome, corneal melt, or corneal dystrophy)
- •Established diagnosis of glaucoma
- •Any condition that, in the investigator's opinion, would interfere with or prolong corneal epithelial healing
- •History of significant eye rubbing or dry eye symptoms
- •History of retinopathy of prematurity resulting in macular ectopia
- •Down syndrome (trisomy 21)
结局指标
主要结局
Mean Change in Best Corrected Visual Acuity in the Amblyopic Eye
时间窗: from randomization to the 8-month primary outcome visit
Treatment group comparison of the change in Best-Corrected ATS-HOTV VA (BCVA) in the amblyopic eye at 8 months after randomization. ATS-HOTV = ATS single-surround HOTV testing protocol
次要结局
- Distribution in Randot Preschool stereoacuity level(at baseline and 8 months)
- Visual Acuity Outcomes(At 8 months)
- Visual Acuity Outcomes at 12 and 24 Months Post-surgery(at 12 and 24 months after surgery)
- Stereoacuity at 12 and 24 Months Post-surgery(at 12 and 24 months after surgery)
- Refractive Error at 12 and 24 Months Post-surgery(at 12 and 24 months after surgery)
- Randot Preschool Stereoacuity Outcomes by Treatment Group(At 8 months after randomization)
- Refractive Error Outcomes in Surgery Group(At 7 months after randomization)
- Distribution of refractive error outcomes(At 7 months after baseline)
研究者
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