The application of non-invasive ventilation during pulmonary rehabilitation in patients with Chronic Obstructive Pulmonary Disease (COPD)

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease; Respiratory; Chronic obstructive pulmonary disease, unspecified

• Registration Number: ISRCTN15832381
• Lead Sponsor: Bristol Royal Infirmary (UK)

Brief Summary

1. 2014 results in https://erj.ersjournals.com/content/44/Suppl_58/P4711.article-info (added 22/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-02-15
• Study Completion: 2015-02-01
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

1. Male and female subjects, aged 40 and above (no upper age limit)
2. Primary diagnosis of COPD
3. Admission for an acute exacerbation on chronic respiratory failure requiring non-invasive ventilation (NIV)
4. Able to mobilize following admission
5. Able to use NIV within the hospital setting during exercise
6. Not attending Pulmonary Rehabilitation or planned to within the study period of three months post discharge

Exclusion Criteria

1. Unable to tolerate/use NIV
2. Unable to mobilize following admission
3. Currently undertaking pulmonary rehabilitation
4. Primary diagnosis is not COPD

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Health related quality of life (QoL) is measured using the EuroQol questionnaire (EQ-5D) (Brooks R, et al, 1996), will be used. The EQ-5D is a patient-completed questionnaire giving a single index value for health status and has been used in COPD patients (Cleland J, et al, 2007; Gonzalez-Moro J, et al, 2009; Harper R, et al, 1997; Heyworth I, et al, 2009; Nilsson E, et al, 2007; Pickard A, et al, 2008; Stahl E, et al, 2003; Stahl et al, 2005; Szende A, et al, 2009;).<br><br> The EQ-5D will be completed as follows ?<br> 1. On admission to the study<br> 2. At point of discharge home<br> 3. At 1, 2 and 3 months of the study.<br><br> Completion of the EQ-5D at time points 1 and 2 will be supervised by the researcher. In all three groups, following discharge, the questionnaire will be posted out to the patients.<br>