Effect of Shorten Gonadotropin-releasing Hormone Agonist Therapy on the Outcome of in Vitro Fertilization-Embryo Transfer in Patients With Endometriosis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
Gonadotropin-releasing hormone analogue (GnRH-a) is a synthetic decapeptide compound which can down-regulate pituitary function causing a temporary low estrogen state. Since endometriosis is an estrogen-dependent disease, the use of long-acting GnRH-a can control the growth of endometriosis by inhibiting ovary function.Some scholars have found that, for adenomyosis patients who received a super long protocol (pretreatment of long-acting GnRH-a for 1-2 months) in IVF treatment, the pregnancy outcome is comparable to that of the controls with normal uterus. Thus, the aim of this study is to compare the clinical pregnancy rate in patients treated with GnRH-a for 1, or 2 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 22 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •first IVF cycle;
- •with normal ovarian reserve(FSH(10miu/ml； antral follicle count )3)
- •with normal uterine
排除标准
- •Pre-implantation genetic diagnosis cycles;
- •Oocyte donation cycles
研究组 & 干预措施
Long term GnRH-a for 1 month
patient in this group only receive GnRH-a 3.75 for 1 month
干预措施: Long term GnRH-a (3.75mg) (Drug)
patient in this group only receive GnRH-a 3.75 for 2 month
patient in this group only receive GnRH-a 3.75 for 2 month
干预措施: Long term GnRH-a (3.75mg) (Drug)
结局指标
主要结局
clinical pregnancy rate
时间窗: 5 weeks after embryo transfer
次要结局
- Number of oocytes retrieved(1 day at oocyte retrieved day)
- 2 pronucleus(2PN)fertilization rate(48hours after oocyte retrieved day)
研究者
Yingpu Sun
Director of Reproductive Medical Center,1st Affilated Hospital, Zhengzhou University
The First Affiliated Hospital of Zhengzhou University