Therapeutic Study of 177Lu-CTR-FAPI in Advanced Metastatic Digestive Malignancies

Not Applicable

Not yet recruiting

• Conditions: Pancreatic Ductal Adenocarcinoma (PDAC); Adenocarcinoma of the Stomach; Colorectal Cancer Metastatic; Neuroendocrine Tumor (NET)
• Interventions: Drug: 177Lu-CTR-FAPI nuclide-targeted therapy

• Registration Number: NCT07014254
• Lead Sponsor: Xijing Hospital

Brief Summary

This was a single-centre, single-arm, non-blinded, prospective study using 20 patients with advanced metastatic GI malignancies recruited to treat patients with advanced metastatic GI malignancies with 177Lu-CTR-FAPI to assess the safety of 177Lu-CTR-FAPI in advanced metastatic GI malignancies; this included radiation therapy dosimetry and initial treatment Determination of Effectiveness

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-05
• Study First Submitted: 2025-05-22
• Study First Submitted QC: 2025-06-08
• Last Update Submitted: 2025-06-08
• Study First Posted: 2025-06-10
• Last Update Posted: 2025-06-10
• Study Start: 2025-06-20
• Primary Completion: 2028-04-30
• Study Completion: 2028-04-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 1. voluntary participation in this study and signing of informed consent;
• 2. age 18-75 years (both 18 and 75 years);
• 3. ECOG (Eastern Cooperative Oncology Group) physical status score: 0-1;
• 4.Advanced metastatic gastrointestinal malignancies with high FAP expression: e.g. neuroendocrine tumours (NET G2, G3), neuroendocrine carcinomas (NEC), pancreatic ductal adenocarcinomas (PDAC), gastric adenocarcinomas, colorectal carcinomas, intrahepatic cholangiocarcinomas (ICC), and squamous carcinomas of the oesophagus. All of the above should be confirmed by 68Ga-FAPI PET/CT with high FAP expression (criterion: more than 50% of lesions with SUVmax ≥10). 5.
• 5. Disease status: locally advanced unresectable or metastatic lesions confirmed by imaging (CT/MRI/PET-CT); at least 1 measurable lesion (RECIST 1.1 criteria).

• 6. good major organ function, i.e. the following criteria are met (no blood components, cell growth factors are allowed within 14 days prior to the first dose)

  7. Creatinine clearance ≥ 50 ml/min (calculated according to the Cockcroft-Gault formula) or serum creatinine ≤ 150 μmol/L;

  8. Urine protein <2+; if urine protein ≥2+, then 24-hour urine protein quantification must show <2 g of protein;

  9. White blood cell count ≥ 2 × 109/L;

  10. Absolute neutrophil count (ANC) ≥ 1.5 × 109/L;

  11. Platelets ≥ 75 × 109/L;

  12. Haemoglobin ≥ 8.0 g/dL;

  13. Serum albumin ≥ 30 g/L.

  14. Total bilirubin ≤ 3 × ULN;

• 7. Women of childbearing age who undergo a blood pregnancy test within 72 h prior to treatment need to be excluded from pregnancy and must be non-lactating and willing to use a highly effective method of contraception for the duration of the trial and for 6 months after completion of treatment. For men, agreement to use a highly effective method of contraception or to have been surgically sterilised during the study and for 4 months after the end of treatment.

Exclusion Criteria

• 1. Disease-related:

  2. Combination of other malignancies (except non-melanoma skin cancer or radical tumours without recurrence within 5 years);

  3. Presence of central nervous system metastases or carcinomatous meningitis;

  4. Uncontrolled cancer pain (requiring long-term high-dose opioids) or cachexia (≥20% weight loss in 6 months);

  5. Diabetes mellitus (fasting blood glucose > 2 x ULN) that is not well controlled with optimal medical supportive therapy;

  6. Accompanied by poorly controlled plasmapheresis, including pleural fluid, ascites, and pericardial effusion; controlled with treatment and stable (asymptomatic, not requiring interventional therapy, and stable on imaging) for ≥2 weeks may be included;

  7. Severe urinary incontinence, hydronephrosis, severe voiding dysfunction or the need for an indwelling urinary catheter for any reason;

  8. Subjects with uncontrolled cardiac clinical symptoms or disease, including but not limited to: i) NYHA class 2 or higher heart failure; ii) unstable angina; iii) myocardial infarction within 1 year prior to enrolment; iv) left ventricular ejection fraction (LVEF) <50%; v) clinically significant supraventricular or ventricular arrhythmias requiring treatment or intervention;

  9. Co-occurring active hepatitis B (HBV-DNA testing is required for HBsAg-positive individuals with HBV DNA ≥500 IU/mL or 2500 copies/mL), and hepatitis C (HCV-Ab-positive and above the lower limit of detection of the analytical method);

  10. Persons known to have acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) testing positive. Persons with active syphilis infection.

• 2. Treatment related

  3. Radiotherapy within 4 weeks or previous radiotherapy to >25% of the bone marrow area;

  4. Received systemic anti-tumour therapy such as chemotherapy, immunotherapy, targeted therapy within 4 weeks;

  5. Treatment with surgery (biopsy puncture, non-anti-tumour surgical operations such as ERCP may be excluded), radiofrequency ablation or cryoablation, interferon, transcatheter arterial embolisation (TAE) or transcatheter arterial chemoembolisation (TACE) within 12 weeks;

  6. Prior FAP-targeted therapy (e.g., FAPI-PRRT, anti-FAP antibody drugs);

  7. Presence of contraindications to radionuclide therapy (e.g., myelodysplastic syndrome, extensive bone metastases with bone marrow failure).

     Comorbidities and Risks:

  8. Previous antineoplastic therapy resulting in toxicity that has not recovered to grade ≤1 according to the NCI-CTCAE v5.0 classification (with the exception of lowered lymphocyte counts, alopecia, and the indicators mentioned in the inclusion criteria, and with the exception of partially tolerable chronic grade 2 toxicity, in the judgement of the investigator).

• 3. Other exclusions

  4. History of allergy to peptide radiopharmaceuticals;

  5. Inability to co-operate with long-term follow-up (e.g., mental illness, geographical constraints, etc.);

  6. Refusal of contraception by pregnant or lactating women or patients of childbearing age.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
177Lu-CTR-FAPI nuclide-targeted therapy	177Lu-CTR-FAPI nuclide-targeted therapy	177Lu-CTR-FAPI nuclide-targeted therapy in patients with advanced tumours lacking effective treatments

Primary Outcome Measures

Name	Time	Method
ORR	End of treatment (12 weeks)	Objective mitigation rate
DCR	End of treatment (12 weeks)	Disease control rate

Trial Locations

Locations (1)

Department of Nuclear Medicine,Xijing Hospital, Fourth Military Medical University, Xi'an, China, Xi'an, Shaanxi Province Recruiting; 🇨🇳 Xi'an, Shaanxi, China