Effectiveness of Lavage With Alcohol - Chlorhexidine for Chemical Matricectomy

Phase 4

• Conditions: Ingrown Toenail
• Interventions: Drug: 70% alcohol - 0.5% clorhexidine; Drug: 70% alcohol

• Registration Number: NCT01844141
• Lead Sponsor: Universidad Complutense de Madrid

Brief Summary

To compare the efficacy of the lavage with 70% alcohol plus 0.5% chlorhexidine versus 70% alcohol in the surgical treatment of ingrown toenails.

Detailed Description

The purpose of this study is to compare the efficacy of the lavage with 70% alcohol plus 0.5% chlorhexidine versus 70% alcohol during the phenolization procedure in the surgical treatment of ingrown toenails in patients undergoing for chemical matricectomy.

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2013-02-11
• Status Verified: 2013-04
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Study First Submitted QC: 2013-04-30
• Last Update Submitted: 2013-04-30
• Study First Posted: 2013-05-01
• Last Update Posted: 2013-05-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Older than 18 with onychocryptosis

Exclusion Criteria

• infection, history of tinea pedis, onychomycosis, paronychia, nail trauma or subungual hematoma, nail deformities and disorders, peripheral vascular disease or diabetes, cardiac disease, history of rheumatic fever, recent antibiotic use or current antimicrobial therapy, history of steroid use and recent nail polish use

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
alcohol - clorhexidine	70% alcohol - 0.5% clorhexidine	Ingrown toenail irrigated using 70% alcohol - 0.5% clorhexidine
70% alcohol	70% alcohol	Ingrown toenail irrigated using 70% alcohol

Primary Outcome Measures

Name	Time	Method
Quantity of phenol recovered in each lavage with each solution	up to 2 weeks	The amounts of phenol in the samples were quantified by a Jasco modular high performance liquid chromatograph HPLC (Jasco International Co Ltd, Japan) equipped with a LG-2080-04 quaternary low-gradient unit, a PU-2080 pump, a DG-2080-54 degasser, an AS-2050-plus autosampler and a UV-2070 plus UV/Vis detector was used. A C18 column Luna (particle size 3 µm, 150 x 4.6 mm) (Phenomenex, Torrance, CA, USA) was selected for the chromatographic separation of the components, adjusting the column temperature to 30 °C (LC Ni-II/ADC oven).

Trial Locations

Locations (1)

Universidad Complutense de Madrid (Podología); 🇪🇸 Madrid, Spain