Investigating the effect of dexamethasone injection in the first 24 hours in preventing kidney scaring in children with pyelonephritis
Phase 3
Recruiting
- Conditions
- Acute pyelonephritis.Vesicoureteral-refluxN13.7
- Registration Number
- IRCT20231226060526N1
- Lead Sponsor
- Sanandaj University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Children from 1 month to 12 years with first episode of fever T > 38°C
having a urinary tract infection and a positive urine culture
The presence of a positive urine culture, which according to the definition includes at least 100000 CFUs/mL from a clean sample obtained with a urine bag, or at least 10000 CFUs/mL from a sample obtained by catheterization, or the growth of any amount of bacteria from a sample obtained by suprapubic aspiration.
Exclusion Criteria
Endocrine disease
Immunosuppressive therapy
Known cancer or uropathy
Those who had an abnormal DMSA before late assessment (at least 6 months follow-up) had a second UTI.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome of presence of renal scar in Dimercaptosuccinic acid renal scan. Timepoint: 6-month follow-up. Method of measurement: Dimercaptosuccinic acid (DMSA) renal scan.
- Secondary Outcome Measures
Name Time Method The presence of kidney scar in children groups A and B with higher Procalcitonin and the acceptability of steroid adjuvant in terms of the amount of treatment and side effects. Timepoint: 6-month follow-up. Method of measurement: Dimercaptosuccinic acid (DMSA) renal scan.