The significance of intraepithelial lymfocytosis without villous atrophy for the diagnosis of celiac disease.

Completed

• Conditions: celiac disease; sprue; 10025477; 10016950

• Registration Number: NL-OMON32813
• Lead Sponsor: Isala Klinieken

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

1. Idiopathic intraepithelial lymfocytosis without villus atrophy (Marsh 1)
2. Accountable
3. Above 18 years of age
4. Written informed consent

Exclusion Criteria

1. Proven celiac disease, Crohn's disease, infection with Helicobacter pylori or Giardia lamblia, small bowel vascular disease
2. Non-accountable
3. Under 18 years of age
4. No written informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome is the prevalence of HLA DQ2 or DQ8.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary outcome is the prevalence of anti-endomysium antibodies and<br /><br>anti-tissue transglutaminase antibodies. Quality of life.</p><br>