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临床试验/CTRI/2026/02/103342
CTRI/2026/02/103342尚未招募4 期

Ridge Width Preservation in Mandibular Multirooted Tooth Extraction: PRF vs. Non-PRF Approaches

未提供1 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2026年3月18日最近更新:

试验速览

阶段
4 期
状态
尚未招募
入组人数
14
试验地点
1

研究概览

简要总结

This clinical study evaluated the effectiveness of Platelet-Rich Fibrin (PRF) in preserving ridge width and enhancing healing following extraction of mandibular multirooted teeth. Tooth extraction often leads to alveolar ridge resorption, compromising future prosthetic or implant rehabilitation. PRF, an autologous platelet concentrate rich in growth factors, has been proposed as a biological aid to improve post-extraction healing outcomes. Fourteen systemically healthy patients requiring mandibular multirooted tooth extraction were divided into two groups: PRF-treated sockets (test group) and sockets allowed to heal naturally without PRF (control group). Clinical and radiographic parameters—including ridge width, ridge height, healing score, bone fill percentage, plaque index, and pocket probing depth—were evaluated at baseline, 3 months, and 6 months using clinical measurements, CBCT, and IOPA radiographs. Results demonstrated that PRF-treated sockets showed significantly better preservation of ridge width and height, faster and more complete soft tissue healing, and higher bone fill percentages compared to the non-PRF group. Radiographic findings confirmed increased bone density and reduced resorption in PRF-treated sites. Additionally, improved periodontal health was observed in the PRF group. The study concludes that PRF is an effective, cost-efficient, and biocompatible adjunct for extraction socket management, particularly in mandibular multirooted teeth, and plays a valuable role in ridge preservation and preparation for future rehabilitation.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Investigator Blinded

入排标准

年龄范围
18.00 Year(s) 至 50.00 Year(s)(—)
性别
All

入选标准

  • 1.Patients requiring extraction of mandibular multirooted teeth due to non-restorable conditions.
  • 2.Systemically healthy individuals aged 18–50 years.
  • 3.Patients with no active infections or systemic diseases that could affect healing.
  • 4.Adequate pre-extraction alveolar bone volume confirmed radiographically.

排除标准

  • 1.Smokers or individuals with habits impacting oral health.
  • 2.Patients with systemic conditions such as diabetes or osteoporosis.
  • 3.History of recent bisphosphonate therapy or radiation therapy in the head and neck region.
  • 4.Pregnant or lactating women.

研究者

发起方
未提供
责任方
Principal Investigator
主要研究者

Dr Mahika Borgave

SMBT DENTAL COLLEGE AND HOSPITAL

研究点 (1)

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