Prevalence of Ocular Surface Disease in Patients with Glaucoma Using Topical Intraocular Pressure-Lowering Medications at Srinagarind Hospital

Not Applicable

Completed

• Conditions: - Ocular surface disease- Glaucoma medication- TBUT- Schirmer test- Lissamine green staining; Glaucoma; Ocular surface disease

• Registration Number: TCTR20130923001
• Lead Sponsor: Faculty of Medicine, Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-08-15
• Study Start: 2013-09-23
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 143

Inclusion Criteria

- Age more than 20 years old
- The subjects must be informed consent
- Diagnosed as primary open angle glaucoma, pseudoexfoliation glaucoma, pigment dispersion glaucoma, ocular hypertension, chronic angle closure glaucoma or juvenile open angle glaucoma
- subjects use IOP lowering agent(s) more than 6 month continuously
- subjects don't have any prior glaucoma surgery

Exclusion Criteria

- subjects who had undergone any surgery which affect tear film
- subjects have eye trauma
- subjects who have any of the disease following
- Autoimmune disorders
. Primary Sjogren syndrome
. Secondary Sjogren syndrome associated with rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis (scleroderma), polymyositis, dermatomyositis, primary biliary cirrhosis
. Graft versus host disease
. Immune reaction after radiation to head and neck
- Infiltrative processes
. Lymphoma
. Amyloidosis
. Hemochromatosis
. Sarcoidosis
. Infectious process
. HIV-diffuse infiltrative lymphadenopathy syndrome
. Trachoma
- Neuropathic dysfunction
. Multiple sclerosis
. Cranial neuropathies (Bell’s palsy, vasculitis)
. Parkinson disease
. Alzheimer disease
- Endocrine dysfunction
. Androgen deficiency
. subject use and drugs that affect tear film
- Antihypertensives : clonidine, propanolol
- Antidepressants : amitriptyline, nortriptyline, fluoxetine
- Benztropine
- Antihistamine : diphenhydramine hydrochloride, loratadine, cetirizine, fexofenadine
- Marijuana
- Thiabendazole
- Diphenoxylate hydrochloride
- subjects who used artificial tear, cyclosporin eye drop, steroids, topical ocular NSAIDs or autologous serum within 3 months
- Subjects who on punctual plug

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ocular surface disease severity TBUT, Schirmer test, lissamine green staining score

Secondary Outcome Measures

Name	Time	Method
Relationship between number of eyedrops and ocular surface disease TBUT, Schirmer test, lissamine green staining score,Relationship between duration of medication and ocular surface disease TBUT, Schirmer test, lissamine green staining score,Relationship between number of types of eyedrop and ocular surface disease TBUT, Schirmer test, lissamine green staining score