The Effect of Lt to Rt Shunt Using Veno-veno-arterial Extracorporeal Membrane Oxygenation (ECMO) on Coronary Oxygenation in Lung Transplantation Patients

Not Applicable

Completed

• Conditions: Interstitial Pulmonary Fibrosis ARDS; COPD (Chronic Obstructive Pulmonary Disease); Lymphangioleiomyomatosis; Primary Pulmonary Hypertension; Bronchiectasis; ARDS (Acute Respiratory Distress Syndrome)
• Interventions: Procedure: Veno-veno-arterial ECMO

• Registration Number: NCT02859194
• Lead Sponsor: Yonsei University

Brief Summary

ECMO(Extracorporeal membrane oxygenation) is being essential for cardiopulmonary failure patients. There are two types of ECMO, which is veno-veno (V-V) that can be used in respiratory failure patients and veno-arterial (V-A) that can be used in cardiac failure patients. V-A ECMO can also be used during lung transplantation, substitution of cardiopulmonary bypass, which can show sufficient performance during operation and better postoperative outcome. However, regarding V-A ECMO circulating from femoral vein to femoral artery, there is a pro blem of differential hypoxia which might influence coronary artery and head vessels. In this prospective study, the investigators are planning to put another ECMO catheter into internal jugular vein which takes a role of left to right shunt, to mitigate the hypoxia of coronary artery.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05-31
• Study First Submitted: 2016-07-21
• Study First Submitted QC: 2016-08-03
• Study First Posted: 2016-08-08
• Primary Completion: 2016-10-14
• Study Completion: 2016-10-14
• Status Verified: 2018-07
• Last Update Submitted: 2018-07-15
• Last Update Posted: 2018-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

1. scheduled for double lung transplantation

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Exclusion Criteria

1. patients who have history of coronary artery occlusive disease
2. patients with arrhythmia

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Veno-veno-arterial ECMO group	Veno-veno-arterial ECMO	-

Primary Outcome Measures

Name	Time	Method
arterial blood oxygen partial pressure (PaO2)	5 min after jugular catheter flow 1,500ml/min

Secondary Outcome Measures

Name	Time	Method
venous blood oxygen partial pressure (PvO2)	5 min after jugular catheter flow 1,500ml/min

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine; 🇰🇷 Seoul, Korea, Republic of