Dutch Parkinson, Cognition and Driving Ability study (DUPARC-drive): An explorative study on driving simulator performance in de novo Parkinson’s Disease patients

niversity Medical Center Groningen0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

•All subjects:
•-Dutch speaking
•-In possession of a driver’s license
•-Active drivers, i.e., having driven at least 300 kilometres in the last year
•-Age 18 to 75
•-Willingness to cooperate and sign written informed consent
•De novo PD subjects:
•-Diagnosis Parkinson’s disease, as confirmed by a neurologist specialized in Parkinson’s Disease, by the UK-Brain Bank Criteria.
•-Disease duration < 3 months, measured after time of diagnosis.

•All subjects:
•-Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness.
•-Use of category III medication.
•De novo PD subjects:
•-History of dopaminergic medication use.
•-Presence of premorbid pathology, i.e. experienced cerebral infarction or chronic depression, non-related to Parkinson’s disease.
•Healthy control subjects:
•-Presence of psychiatric disorders, i.e. depression or psychosis.
•-History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic strokes).

发起方