The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery
Not Applicable
Recruiting
- Conditions
- Acute Kidney InjuryPediatric Cardiac Surgery
- Interventions
- Drug: Albumin solutionDrug: Crystalloid solutions
- Registration Number
- NCT06710353
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following cardiopulmonary bypass.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 190
Inclusion Criteria
- Pediatric patients under 7 years of age undergoing cardiac surgery with cardiopulmonary bypass
- Preoperative serum albumin level of 4.0 g/dL or lower
Exclusion Criteria
- abnormal preoperative creatinine level
- history of dialysis
- liver dysfunction
- diabetes
- history of hypersensitivity to albumin
- coagulation disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Albumin group Albumin solution A 20% albumin solution is administered over a period of one hour, starting at the time of anesthesia induction. Control group Crystalloid solutions The same volume of crystalloid solution as the administered albumin is infused.
- Primary Outcome Measures
Name Time Method incidence of acute kidney injury (AKI) assessed up to postoperative day 7 The difference in the incidence of acute kidney injury (AKI) between groups, as measured by the KDIGO criteria
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does preoperative albumin modulate inflammatory pathways like NF-κB to prevent AKI in pediatric cardiac surgery?
What is the comparative efficacy of albumin vs. crystalloids in reducing AKI incidence post-cardiopulmonary bypass in hypoalbuminemic pediatric patients?
Which biomarkers (e.g., NGAL, IL-6) predict response to preoperative albumin in preventing AKI after pediatric cardiac surgery?
What are the potential adverse events of preoperative albumin administration in hypoalbuminemic pediatric cardiac surgery patients?
Are there combination therapies with albumin and nephroprotective agents like N-acetylcysteine that enhance AKI prevention in pediatric cardiac surgery?
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of